摘要
目的:评估、比较中老年期慢性精神分裂症患者与首次发病患者代谢综合征(MS)的患病率及其差异。方法:本研究于2014年1月-2018年12月横断面调查55~64岁精神分裂症患者353例,其中慢性精神分裂症患者261例(研究组),搜集相关资料,以2017年中国2型糖尿病防治指南有关标准进行MS诊断,并与首次发病未治疗的精神分裂症患者92例(对照组)进行MS、腹型肥胖、血脂异常、高血压病及糖尿病等患病率的比较。结果:研究组患者阳性和阴性症状评定量表(positive and negative symptom scale,PANSS)评分(97.5±14.1)分、HDL-C(1.27±0.29)mmol/L明显低于对照组的(103.7±14.2)分、(1.46±0.38)mmol/L,差异均有统计学意义(P<0.05);研究组的腰围(87.6±7.67)cm、体质指数(24.1±3.1)kg/m^2、空腹血清TG(1.54±1.19)mmol/L、均高于对照组的(82.8±6.6)cm、(21.7±2.6)kg/m^2、(1.18±0.49)mmol/L,差异均有统计学意义(P<0.05);研究组MS患病率(29.9%)、腹型肥胖(41.4%)、血清高TG(30.7%)患病率高于对照组(10.9%、12.0%、15.2%),差异均有统计学意义(P<0.05)。结论:中老年期慢性精神分裂症患者MS患病率明显高于首次发病者,而且主要表现为腹型肥胖和高甘油三酯血症,临床医护人员有必要对此加强监测和防治其风险。
Objective:To evaluatethe prevalenceand differenceof metabolic syndrome(MS)between senile and pre-senilepatients with chronic schizophrenia and first-episode,drug-naive patients(FEPs).Method:A cross-sectional investigation was conducted from January 2014 to December 2018.The study recruited 353 patients with schizophrenia aged from 55 to 64 years,261 of which were with chronic schizophrenia and had received long-term antipsychotics treatment(the study group),and 92 were FEPs(the control group).Relevant information was extracted,and presence of MS was assessed based on the Chinese Diabetes Society diagnostic criteria of MS(2017 edition).Comparisons on the prevalent rates of MS,centre obesity,dyslipidemia,hypertension and diabetes between the two groups were made.Result:The score of positive and negative symptom scale(PANSS)and HDL-C in the study group were(97.5±14.1)points and(1.27±0.29)mmol/L,which were significantly lower than(103.7±14.2)points and(1.46±0.38)mmol/L in the control group(P<0.05).Compared with the control group,the study group had a significantly larger waist circumference[(87.6±7.67)cm vs(82.8±6.6)cm]and higher BMI[(24.1±3.1)kg/m^2 vs(21.7±2.6)kg/m^2],serum fasting triglyceride[(1.54±1.19)mmol/L vs(1.18±0.49)mmol/L],the differences were statistically significant(P<0.05).The detected rates were also significantly higher in the study group than those in the control regarding the prevalence rates of MS(29.9%vs 10.9%),centre obesity(41.4%vs 12.0%)and serum triglyceride(30.7%vs 15.2%),the differences were statistically significant(P<0.05).Conclusion:Senile and pre-senile patients with chronic schizophrenia have a significantly higher prevalence of MS than FEPs,especially in the dominant components of centre obesity and serum triglyceride.MS in these schizophrenic patients should be more carefully monitored,prevented and controlled to minimize the risks.
作者
陈剑英
程文桃
林瑞钱
郭少楠
黄婷
高明
郑典诚
林蔚清
陈元生
CHEN Jianying;CHENG Wentao;LIN Ruiqian;GUO Shaonan;HUANG Ting;GAO Ming;ZHENG Diancheng;LIN Weiqing;CHEN Yuansheng(Fuzhou Neuro-psychiatry Hospital,Fuzhou 350008,China;不详)
出处
《中外医学研究》
2020年第19期40-42,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
福州市科技计划项目(2015-S-146-3)
福州市临床重点专科建设项目(201710271)。
