摘要
目的探讨应用富血小板血浆(PRP)对股骨颈骨折治疗效果的影响。方法选择2016年4月至2018年4月于揭阳市人民医院骨一科治疗的100例股骨颈骨折患者为研究对象,以随机数表法分为观察组和对照组,每组50例。对照组行单纯空心钉内固定手术,观察组在对照组基础上联合PRP治疗。持续注入PRP 5周后,比较两组患者的临床疗效、治疗前后的端骨密度、人工全髋关节疗效评分(Harris评分),以及住院时间、骨折愈合时间和并发症的发生情况。结果治疗后,观察组患者的治疗总有效率为94.0%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);治疗前,两组患者的端骨密度比较差异无统计学意义(P>0.05);治疗后,两组患者的骨密度明显提高,且观察组的骨密度为(1.85±0.35)g/cm^2,明显高于对照组的(1.05±0.26)g/cm^2,差异均有统计学意义(P<0.05);治疗前,两组患者的Harris评分比较差异无统计学意义(P>0.05);治疗后,两组患者的Harris评分明显升高,且观察组的Harris评分为(80.55±7.14)分,明显高于对照组的(73.36±6.04)分,差异均有统计学意义(P<0.05);观察组患者的住院时间和骨折愈合时间分别为(23.78±9.15)d、(8.26±1.54)个月,明显短于对照组的(27.86±7.84)d、(9.17±2.14)个月,差异均有统计学意义(P<0.05);观察组患者的并发症总发生率为4.0%,明显低于对照组的18.0%,差异有统计学意义(P<0.05)。结论富血小板血浆能促进股骨颈骨折患者骨折端愈合,提高端骨密度,缩短恢复时间,减少并发症发生,值得临床推广应用。
Objective To study the curative efficacy of platelet-rich plasma(PRP)in the femoral neck fracture.Methods A total of 100 patients with femoral neck fracture treated in First Department of Orthopaedics,Jieyang People’s Hospital from April 2016 to April 2018 were selected as the study subjects.According to random number table method,the patients were divided into the observation group(n=50)and control group(n=50).The control group was treated with simple hollow nail internal fixation,and the observation group received the treatment of platelet-rich plasma PRP on the basis of the treatment of the control group.Postoperative clinical efficacy,end bone density,Harris score,length of stay,fracture healing time,and complications were recorded and compared between the two groups.Results Five weeks after operation,the total effective rate of the observation group was 94.0%,which was significantly higher than 80.0%of the control group(P<0.05).Before treatment,there was no statistically significant difference in bone mineral density between the two groups(P>0.05);after treatment,the femoral density of the two groups was significantly increased;the density in observation group was(1.85±0.35)g/cm^2,which was significantly larger than(1.05±0.26)g/cm^2 of the control group(P<0.05).Before the treatment,there was no significant difference in Harris score between the two groups(P>0.05);after the treatment,Harris score of the two groups was significantly increased,and the Harris score of the observation group was(80.55±7.14)points,which was significantly higher than(73.36±6.04)points of the control group(P<0.05).After treatment,the length of hospital stay and fracture healing time in the observation group were(23.78±9.15)d and(8.26±1.54)months,which were significantly better than corresponding(27.86±7.84)d and(9.17±2.14)months in the control group(P<0.05).After treatment,the total incidence of complications in the observation group was 4.0%,which was significantly lower than 18.0%in the control group(P<0.05).Conclusion The application of PRP has obvious therapeutic effect on femoral neck fracture healing,which can improve bone density,promote fracture healing,shorten recovery time and reduce complications.
作者
李裕祥
江洪耿
陈镇鑫
LI Yu-xiang;JIANG Hong-geng;CHEN Zhen-xin(First Department of Orthopaedics,Jieyang People's Hospital,Jieyang 522095,Guangdong,CHINA)
出处
《海南医学》
CAS
2020年第14期1815-1817,共3页
Hainan Medical Journal
关键词
股骨颈骨折
富血小板血浆
骨密度
人工全髋关节疗效评分
疗效
Fracture of femoral neck
Platelet rich plasma(PRP)
Bone mineral density
Total hip arthroplasty score
Curative effect
