摘要
目的了解绵阳地区泌尿生殖道感染患者支原体感染情况及对抗菌药物的敏感性,为临床合理的用药提供参考依据。方法收集绵阳科学城医院2019年1~12月泌尿生殖道感染患者1330例,采用支原体药敏试剂盒培养及鉴定,并与9种抗菌药物进行药敏试验,分析其耐药情况。结果1330例患者中支原体阳性777例,阳性率为58.42%,其中解脲脲原体(Uu)阳性645例,阳性率48.50%;人型支原体(Mh)阳性132例,阳性率9.92%;Uu+Mh混合感染阳性119例,阳性率8.95%。女性Uu阳性检出率高于男性,差异有统计学意义(P<0.05);不同性别Mh和Uu+Mh混合感染阳性检出率比较,差异无统计学意义(P>0.05)。药敏结果显示,Uu感染的抗菌药物敏感率以米洛环素(97.05%)最高,耐药率以氧氟沙星(32.44%)最高,中介率以左旋氧氟沙星(72.80%)最高;Mh感染的抗菌药物敏感率以米洛环素(94.52%)最高,耐药率以阿奇霉素(92.52%)最高,中介率以左旋氧氟沙星(39.51%)最高。结论绵阳地区的支原体感染率较高,主要以Uu感染为主,女性患者多于男性,主要集中于20~40岁年龄段,对氟喹诺酮类和大环内脂类抗菌素药物的耐药率高。临床应参照药敏试验结果选用抗菌药物,以减少耐药菌株的产生,米诺环素、多西环素、交沙霉素可作为临床支原体感染的首选药物。
Objective To understand mycoplasma infection in patients with genitourinary tract infections in Mianyang area and its sensitivity to antibacterial drugs,so as to provide a reference for clinically reasonable medication.Methods A total of 1,330 patients with genitourinary tract infections from January to December 2019 in Mianyang Science City Hospital were collected,cultured and identified using Mycoplasma drug sensitivity kits,and drug sensitivity tests were conducted with 9 antibacterial drugs to analyze their drug resistance.Results Among the 1330 patients,777 were positive for Mycoplasma,the positive rate was 58.42%,of which 645 were positive for Ureaplasma urealyticum(Uu),and the positive rate was 48.50%;132 were positive for Mycoplasma hominis(Mh),and the positive rate was 9.92%;There were 119 positive cases of Uu+Mh mixed infection,with a positive rate of 8.95%.The Uu positive detection rate of females was higher than that of males,the difference was statistically significant(P<0.05);the positive detection rate of Mh and Uu+Mh mixed infections of different genders was not statistically significant(P>0.05).The drug sensitivity results showed that the antimicrobial sensitivity rate of Uu infection was Milocycline(97.05%),the resistance rate was ofloxacin(32.44%),and the mediation rate was levofloxacin(72.80%).The antimicrobial sensitivity rate of Mh infection is Milocycline(94.52%),the resistance rate is Azithromycin(92.52%),and the mediation rate is levofloxacin(39.51%).Conclusion Mycoplasma infection rate is higher in Mianyang area,mainly Uu infection,female patients are more than men,mainly concentrated in the 20-40 age group,and the resistance rate to fluoroquinolones and macrolide antibiotics is high.Clinically,antimicrobial drugs should be selected according to the results of drug susceptibility tests to reduce the production of drug-resistant strains.Minocycline,doxycycline,and glucomycin can be used as the first choice for clinical mycoplasma infections.
作者
姚佳欣
蒋雪梅
YAO Jia-xin;JIANG Xue-mei(Department of Laboratory Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Laboratory Medicine,Mianyang Science City Hospital,Mianyang 621000,Sichuan,China)
出处
《医学信息》
2020年第14期134-136,共3页
Journal of Medical Information
关键词
解脲脲原体
人型支原体
药物敏感性试验
Ureaplasma urealyticum
Mycoplasma hominis
Drug sensitivity test
