摘要
目的探讨胸腺五肽联合噻托溴铵治疗慢性阻塞性肺疾病(COPD)的疗效。方法选择2017年8月~2019年1月我院收治的94例COPD患者,采用随机数表法分为对照组(47例)和观察组(47例)。对照组给予噻托溴铵粉吸入剂治疗,观察组在此基础上给予胸腺五肽治疗,比较两组肺功能指标[第1s内用力呼气量(FEV1)、最大呼气流速峰值(PEFR)、肺活量(FVC)及FEV1/FVC]、T淋巴细胞亚群[CD3^+、CD4^+、CD8^+、CD4^+/CD8^+]。结果观察组治疗后FEV1、PEFR、FVC及FEV1/FVC均高于对照组,差异有统计学意义(P<0.05);观察组治疗后CD3^+、CD4^+及CD4^+/CD8^+显著高于对照组,CD8^+低于对照组,差异有统计学意义(P<0.05)。结论在COPD治疗中采用胸腺五肽联合噻托溴铵治疗的效果较好,能显著改善患者的免疫功能,促进肺功能的恢复。
Objective To investigate the efficacy of thymopentin combined with tiotropium bromide in treatment of chronic obstructive pulmonary disease(COPD).Methods 94 patients with COPD who admitted in the hospital from August 2017 to January 2019 were divided into control group(47 cases)and observation group(47 cases)according to random number table.Control group was given tiotropium bromide powder for inhalation,and observation group was treated with thymopentin based on control group.The pulmonary function indexes[forced expiratory volume in first second(FEV1),peak expiratory flow rate(PEFR),forced vital capacity(FVC),FEV1/FVC]and T-lymphocyte subsets[CD3^+,CD4^+,CD8^+,CD4^+/CD8^+]were compared between two groups.Results After treatment,the FEV1,PEFR,FVC and FEV1/FVC in observation group were higher than those in control group(P<0.05);After treatment,the CD3^+,CD4^+and CD4^+/CD8^+in observation group were higher than those in control group,and the CD8^+in observation group was lower than that in control group(P<0.05).Conclusion Thymopentin combined with tiotropium bromide in treatment of COPD is effective,it can improve immune function and promote recovery of pulmonary function.
出处
《首都食品与医药》
2020年第14期54-56,共3页
Capital Food Medicine
关键词
慢性阻塞性肺疾病
胸腺五肽
噻托溴铵
肺功能
免疫功能
chronic obstructive pulmonary disease
thymopentin
tiotropium bromide
pulmonary function
immune function
