摘要
目的探讨老年2型糖尿病(T2DM)患者血清Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素(OC)、Ⅰ型前胶原N-端前肽(PINP)、25-羟维生素D3[25(OH)D3]表达变化及与血糖、胰岛素水平的关联性。方法选取2017年5月至2019年12月老年T2DM患者120例为T2DM组,同期86例健康体检者为健康组。测定对比两组血清β-CTX、OC、PINP、25(OH)D3与血糖指标[餐后2h血糖(2 hPG)、空腹血糖(FPG)]、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平,应用Pearson分析老年T2DM患者血清β-CTX、OC、PINP、25(OH)D3表达与血糖指标、胰岛素指标的关联性,多元线性回归分析影响血糖、胰岛素指标的有关因素。结果T2DM组血清β-CTX、PINP水平高于健康组,血清OC、25(OH)D3水平低于健康组,2 hPG、FPG水平和FINS、HOMA-IR水平高于健康组(P均<0.01);老年T2DM患者血清β-CTX、PINP水平与2 hPG、FPG、FINS、HOMA-IR水平呈正相关,血清OC、25(OH)D3水平与2 hPG、FPG、FINS、HOMA-IR水平呈负相关(P均<0.01);血清β-CTX、OC、PINP、25(OH)D3均为患者血糖、胰岛素指标的重要影响因素(P均<0.01)。结论老年T2DM患者血清β-CTX、OC、PINP、25(OH)D3表达明显异常,并与血糖、胰岛素指标显著相关。
Objective To investigate the expression of serumβcross-linked C-telopeptide of typeⅠcollagen(β-CTX),osteocalcin(OC),type I procollagen N-terminal propeptide(PINP),and 25-hydroxyvitamin D3[25(OH)D3]in elderly patients with type 2 diabetes(T2 DM)and their correlation with blood glucose and insulin levels.Methods From May 2017 to December 2019,120 elderly T2 DM patients were selected as the T2 DM group,and 86 healthy people during the same period were selected as the healthy group.The levels of serumβ-CTX,OC,PINP,25(OH)D3,and blood glucose and insulin indexes were measured and compared between the two groups.Pearson analysis was used to analyze the correlation between serumβ-CTX,OC,PINP,25(OH)D3 expression and blood glucose and insulin indexes in elderly T2 DM patients.Multiple linear regression was used to analyze the related factors affecting blood glucose and insulin indexes.Results The levels of serumβ-CTX and PINP in the T2 DM group were higher than those in the healthy group,and the levels of serum OC and 25(OH)D3 were lower than those in the healthy group,while the levels of 2 hPG,FPG,FINS and HOMA-IR in T2 DM group were higher than those in healthy group(all P<0.05).Serumβ-CTX and PINP levels were positively correlated with 2 hPG,FPG,FINS,and HOMA-IR levels in elderly T2 DM patients,and serum OC,25(OH)D3 levels were negatively correlated with 2 hPG,FPG,FINS,and HOMA-IR levels(all P<0.01).Serumβ-CTX,OC,PINP,and 25(OH)D3 were all important factors influencing blood glucose and insulin indexes(all P<0.01).Conclusion Serumβ-CTX,OC,PINP,and 25(OH)D3 expression in elderly T2 DM patients are significantly abnormal,and are significantly correlated with blood glucose and insulin indicators.
作者
陈建丰
韩晓芳
翟斐
宋佳佳
尹德超
石珍珍
刘克梅
张新秀
CHEN Jian-feng;HAN Xiao-fang;ZHAI Fei;SONG Jia-jia;YIN De-chao;SHI Zhen-zhen;LIU Ke-mei;ZHANG Xin-xiu(Department of Endocrinology,The Second People's Hospital of Hefei,Hefei,Anhui 230011,China)
出处
《中国临床研究》
CAS
2020年第7期959-962,共4页
Chinese Journal of Clinical Research
基金
安徽省自然科学基金项目(1808085MH284)。
