摘要
以聚乙二醇4000(PEG-4000)、聚乙二醇6000(PEG-6000)和聚乙烯吡咯烷酮K30(PVP-K30)为载体,采用溶剂-熔融法和溶剂法制备联苯菊酯固体分散体。利用FT-IR、XRD、SEM对固体分散体的结构进行表征,以体外溶出度为评价指标,筛选出最佳载体及最佳药载比。结果表明,以上3种载体均可不同程度提高联苯菊酯的体外溶出,其中以PVP-K30为载体、药载比为1∶6的制品溶出效果最好,2 h溶出率达到90%以上。分析结果显示药物以无定形形式存在于载体中。
By using polyethylene glycol 4000(PEG-4000),polyethylene glycol 6000(PEG-6000)and polyvinylpyrrolidone K30(PVP-K30)as carrier respectively,bifenthrin solid dispersions are prepared through solventmelting and solvent methods.Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and scanning electron microscopy(SEM)are utilized to characterize the structures of bifenthrin solid dispersions.Taking the in vitro dissolution as an evaluation indicator,the best carrier and the optimum drug loading ratio are screened out.The results show that all three carriers can increase the in vitro dissolution of bifenthrin in different degrees,the solid dispersion with PVP-K30 as carrier and a drug loading ratio of 1∶6 has the best in vitro dissolution effect,and the dissolution rate exceeds 90%in 2 h.FTIR,XRD and SEM analysis shows that the drug has been presented within PVP-K30 in an amorphous form.
作者
章乐乐
程松波
胡航
徐德锋
ZHANG Le-le;CHENG Song-bo;HU Hang;XU De-feng(School of Pharmaceutical Engineering&Life Science,Changzhou University,Changzhou 213164,China)
出处
《现代化工》
CAS
CSCD
北大核心
2020年第7期141-144,149,共5页
Modern Chemical Industry
基金
江苏省“双创计划”-双创团队项目(苏人才办[2017]37号)。
关键词
联苯菊酯
固体分散体
溶解度
体外溶出
表征
bifenthrin
solid dispersion
solubility
in vitro dissolution
characterization
