摘要
目的探讨胃肠道恶性肿瘤患者化疗相关性贫血的发生情况及对患者预后和生活质量的影响。方法选取行化疗的180例胃肠道恶性肿瘤术后患者,探讨化疗相关性贫血的发生情况及其与患者临床特征、预后及生活质量的关系。结果化疗前后,180例胃肠道恶性肿瘤患者中,共137例患者发生贫血,其中,化疗前有21例(11.67%),化疗后有116例(64.44%)。化疗前后,患者的血红蛋白水平分别为(133.88±10.65)g/L、(87.61±6.42)g/L,差异有统计学意义(P <0.01)。化疗相关性贫血与胃肠道恶性肿瘤患者的年龄、血清白蛋白水平、临床分期、体力状态(PS)评分、化疗周期均可能有关(P<0.05),但与胃肠道恶性肿瘤患者的性别、肿瘤类型均可能无关(P>0.05)。化疗后,发生化疗相关性贫血的胃肠道恶性肿瘤患者角色功能、躯体功能、情绪功能、社会功能、认知功能评分及总评分均明显低于未发生贫血的胃肠道恶性肿瘤患者(P<0.01)。结论胃肠道恶性肿瘤患者化疗相关性贫血的发生率较高,年龄、血清白蛋白水平、临床分期、PS评分、化疗周期均可能引发化疗相关性贫血。化疗相关性贫血不仅可缩短胃肠道恶性肿瘤患者的生存期,还会影响化疗效果。
Objective To investigate the incidence of chemotherapy-induced anemia(CIA) in patients with gastrointestinal tumors and theimpact on prognosis and quality of life.Method A retrospective analysis was performed for 180 patients with gastrointestinal tumors treated with chemotherapy,to evaluate the incidence of CIA and the relationship with the clinical characteristics,prognosis and quality of life of those patients.Result There were 137 cases of CIA indentified in this cohort of patients with malignant gastrointestinal tumor before and after chemotherapy,21 cases(11.67%) of CIA were diagnosed before chemotherapy,and another 116 cases(64.44%) developed CIA after chemotherapy.The hemoglobulin level in these patient was(133.88±10.65) g/L versus(87.61±6.42) g/L before and after chemotherapy,and the difference was of statistical significance(P<0.01).CIA was likely associated with age,serum albumin level,clinical stage,performance status(PS) score and chemotherapy cycles in patients with gastrointestinal tumor(P<0.05),while possibly independent of patient’s gender and tumor typs(P>0.05).After chemotherapy,the scores regarding role,physical,emotional,social,cognitive functions and total scores of patients with CIA were significantly lower than those of patients without CIA(P<0.01).Conclusion The incidence rate of chemotherapy-related anemia in patients with gastrointestinal tumors is relatively high.Age,serum albumin level,clinical stage,PS score and chemotherapy cycles may cause the occurrence of chemotherapy-related anemia,which not only reduces the survival time of patients with malignant gastrointestinal tumors but also affects the effect of chemotherapy.
作者
赵敏艳
陈丽佳
ZHAO Minyan;CHEN Lijia(Department of Oncology,the Second Affiliated Hospital of Suzhou University,Suzhou 215004,Jiangsu,China)
出处
《癌症进展》
2020年第13期1327-1330,共4页
Oncology Progress
关键词
胃肠道恶性肿瘤
化疗相关性贫血
化疗
疗效
预后
生活质量
malignant gastrointestinal tumor
chemotherapy-induced anemia
chemotherapy
efficacy
prognosis
quality of life
