摘要
炎症性肠病(IBD)是由自身免疫紊乱所导致的一种慢性、反复发作的肠道炎症。包括克罗恩病(CD)和溃疡性结肠炎(UC),可由多种因素如环境、肠道菌群失调等诱发。TNF-α一直被认为在IBD的发生、发展过程中起有重要作用,本文就其作用机制作一综述。
Inflammatory bowel disease(IBD)is a chronic and recurrent inflammation of gastrointestinal tract caused by disorder of immune system.It includes Crohn’s disease(CD)and ulcerative colitis(UC).Many factors such as environment and dysbiosis of gut microbiota can lead to IBD.TNF-αis generally considered as playing an important role in the development and progression of IBD.This article reviewed the role of TNF-αin the pathogenesis of IBD.
出处
《胃肠病学》
2020年第3期187-190,共4页
Chinese Journal of Gastroenterology
关键词
炎症性肠病
肿瘤坏死因子Α
炎症
肠外表现
Inflammatory Bowel Disease
Tumor Necrosis Factor-alpha
Inflammation
Extraintestinal Manifestations
