摘要
氧化三甲胺依赖肠道菌群参与动脉粥样硬化的发生发展。通过调节肠道菌群,减少氧化三甲胺形成,可能成为防治心血管疾病新的有效途径。现代中医学认为,动脉粥样硬化与脾胃关系密切;临床研究显示,肠道菌群失调是中医脾胃失其健运的一个生物学基础,临床从脾胃论治动脉粥样硬化显示有一定疗效。本文拟从氧化三甲胺与肠道菌群、中医脾胃、动脉粥样硬化的相关性入手,结合中医学理论和现代医学认识,论述中医学从脾胃治疗动脉粥样硬化的前景。
It showed that plasma trimethylamine N-oxide(TMAO)was associated with the development of atherosclerosis(AS)depending on intestinal microbiota.Reducing the formation of TMAO by regulating intestinal microbiota,it might be a new potential therapeutic target in the treatment of cardiovascular diseases.In Chinese medicine,it was considered that AS was connected with the function of Pi and Wei.In clinical studies,evidence showed that intestinal dysbacteriosis was one of the biological foundations of Pi and Wei weakness and it had definite therapeutic effect in treating AS from Pi and Wei.This study starts with the association among TMAO,intestinal microbiota,Pi and Wei,and AS,based on the theory of traditional Chinese medicine and Western medicine,to discuss the therapeutic prospect for AS from Pi and Wei.
作者
王少丽
史大卓
WANG Shao-Li;SHI Da-zhuo(Department of Gastroenterology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;Cardiovascular Diseases Center,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2020年第7期854-857,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
氧化三甲胺
肠道菌群
脾胃
动脉粥样硬化
trimethylamine N-oxide
intestinal microbiota
Pi and Wei
atherosclerosis
