摘要
目的探讨利用认知筛查工具蒙特利尔认知评估(MoCA)量表预测认知转归的可行性。方法回顾性收集286例老年人先后两次认知评估的分数,根据基线得分分为正常对照组(NC)、轻度认知损害组(MCI)和痴呆组(D)。在各组内分别以MoCA基线单项得分与MMSE、MoCA总分变化值做偏相关分析。结果在NC组MMSE总分、立方体、注意和计算与分数变化值显著相关,MCI组的视空间与执行、画钟指针和数字顺背与分数变化值显著相关,痴呆组的抽象与分数变化值显著相关。结论认知转归受病情变化、干预治疗、学习效应、回归平均值效应等共同影响,执行功能受损可能是阿尔兹海默症的早期指标。
Objective To examine the use of Montreal Cognitive Assessment(MoCA)scale for prediction of cognitive outcome.Methods Data from 286 elderly patients who had performed cognitive assessment twice or more were obtained retrospectively,and divided into Normal Control(NC),Mild Cognitive Impairment(MCI)and dementia groups according to their baseline performance.The correlations between each item scores of MoCA and total score change at follow up were compared within groups.Results Total score change was significantly correlated to the MMSE,cube,attention and subtraction in NC group;visuospatial/executive,clock-hands and digit-backward in MCI group;and abstraction in dementia group.Conclusion Cognitive prognosis is influenced by the course of disease,interventions,learning effect and regression to the mean.Executive function decline can be considered as the early sign of Alzheimer’s disease.
作者
秦若梦
罗财妹
李梦春
赵辉
柏峰
徐运
QIN Ruomeng;LUO Caimei;LI Mengchun(Department of Neurology,Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210008,China)
出处
《中风与神经疾病杂志》
CAS
2020年第6期494-497,共4页
Journal of Apoplexy and Nervous Diseases
基金
国家自然科学基金(No.81771157)。
关键词
蒙特利尔认知评估量表
轻度认知损害
痴呆
回归平均值
执行功能
Montreal Cognitive Assessment(MoCA)
Mild Cognitive Impairment(MCI)
Dementia
Regression to the mean
Executive function
