摘要
叶酸具有受体靶向性、无免疫原性和便于修饰等优异性能,壳聚糖及其衍生物具有良好的生物相容性、粘附性、生物可降解性等优异性能,叶酸-壳聚糖及其衍生物的偶联物兼备二者的优点,在生物医学领域具有广阔的应用前景。综述了国内外学者近几年关于叶酸-壳聚糖偶联物在载药体系方面的研究进展,最后结合叶酸-壳聚糖偶联物在制备方法、体内释放、未来研究方向等方面进行了总结和展望。
Folic acid has excellent properties such as receptor targeting,non-immunogenicity,and easy modification.Chitosan and its derivatives also have good properties such as biocompatibility,adhesion,and biodegradability.The folic acid-chitosan and its derivatives has the advantages of chitosan and folic acid,and has broad application prospects in the field of biomedicine.Therefore,the article reviews the research progress of folic acid-chitosan conjugates in drug loading systems in recent years and summarized and prospected in terms of preparation methods,in vivo release,and future research directions.
作者
陆钊
张怡之
胡志刚
张俊伟
丁馨怡
刘茂顺
刘佳豪
LU Zhao;ZHANG Yi-zhi;HU Zhi-gang;ZHANG Jun-wei;DING Xin-yi;LIU Mao-shun;LIU Jia-hao(School of Pharmacy,Jilin Medical University,Jilin 132000,China;School of Inspection,Jilin Medical University,Jilin 132000,China;Carbide Plant of Jilin Petrochemical Company,Jilin 132000,China;School of Pharmacy,Yanbian University,Yanbian 133000,China)
出处
《化学试剂》
CAS
北大核心
2020年第7期803-812,共10页
Chemical Reagents
基金
吉林省大学生创新创业训练计划项目(20174033)
吉林医药学院大学生创新创业训练项目(201853)。
