摘要
目的探讨合并抑郁的帕金森患者应用丁苯酞联合舍曲林的治疗效果。方法将我院2017年2月~2019年2月收治的合并抑郁的帕金森病患者60例随机分组:采取常规方案治疗(对照组,n=30)与采取加用丁苯酞联合舍曲林给药方案治疗(观察组,n=30),比较两组患者总有效率、帕金森病症状、抑郁症状、血液指标水平。结果观察组帕金森并抑郁患者总有效率经评定为96.67%,高于对照组的76.67%(P<0.05)。两组开展治疗前,帕金森病评定量表(UPDRS)评分经测定无差异(P>0.05),治疗后各组测定值均有降低,且观察组降低程度较对照组更为显著(P<0.05)。两组开展治疗前,抑郁自评量表(HAMD)评分经测定无差异(P>0.05),治疗后,各组测定值均有降低,且观察组降低程度较对照组更为显著(P<0.05)。两组开展治疗前,血液学指标重组人帕金森蛋白7(PARK7)、神经营养因子3(NT-3)、C反应蛋白(CRP)经测定无差异(P>005),治疗后,PAPK7、CRP均有降低,NT-3均有升高,且观察组降低和升高程度较对照组更为显著(P<0.05)。结论合并抑郁的帕金森患者应用丁苯酞联合舍曲林给药方案治疗,可增强临床效果,改善帕金森及抑郁症状,保护神经细胞、对神经功能恢复具促进作用。
Objective To investigate the efficacy and prognosis of princebenzine combined with sertraline in patients with Parkinson's disease and depression.Methods Sixty Parkinson's disease patients with depression were enrolled.All patients were admitted to our hospital from February 2017 to February 2019.They were randomized divided into two groups:treated with conventional regimen(control group,n=30)and treated with princebenzine combined with sertraline(observation group,n=30).The total effective rate,recovery of symptoms of Parkinson's disease,recovery of depressive symptoms,and hematological index were compared between two groups.Results The total effective rate in the observation group was 96.67%,which was higher than that(76.67%)in the control group(P<0.05).Before treatment,there was no difference in UPDRS score between the two groups(P>0.05).After treatment,the measured values of each group decreased,and the degree of reduction in the observation group was more significant than that in the control group(P<0.05).Before treatment,there was no difference in the self-rating depression scale(HAMD)score between the two groups(P>0.05).After treatment,the measured values of each group decreased,and the degree of reduction in the observation group was more significant than that in the control group(P<0.05).Before treatment,there was no difference in the hematological indexes of recombinant human Parkinson protein 7(PARK7),neurotrophic factor 3(NT-3),and C-reactive protein(CRP)between the two groups(P>005).After treatment,both PAPK7 and CRP decreased and NT-3 increased,and the degree of changes in the observation group was more significant than that in the control group(P<0.05).Conclusion The butylphthalide combined with sertraline can enhance clinical outcomes,improve Parkinson's and depressive symptoms,protect nerve cells,and promote neurological recovery in Parkinson's disease patients with depression.
作者
侯新鸽
叶建
宋允章
HOU Xinge;YE Jian;SONG Yunzhang(Department of Neurology,Zhouzhi County People's Hospital,Xi'an 710400,China)
出处
《国际精神病学杂志》
2020年第3期540-542,546,共4页
Journal Of International Psychiatry
关键词
帕金森病
抑郁
丁苯酞
症状
Parkinson's disease
Depression
Butylphthalide
Symptoms
