摘要
目的评价经皮射频消融(RFA)与125I放射性粒子植入术联合治疗直径>5 cm的乏血供肝恶性肿瘤的临床效果。方法回顾分析2013年1月至2016年6月行微创介入治疗的乏血供肝恶性肿瘤患者80例,根据治疗方式分为两组,RFA联合125I放射性粒子植入术(联合治疗组)47例,单纯行TACE(对照组)33例,比较两组的疗效、总生存期(OS)和不良反应。结果联合治疗组的客观缓解率(ORR,87.2%)及疾病控制率(DCR,95.7%)均高于对照组(ORR 66.7%,DCR 81.8%),差异均有统计学意义(P<0.05);联合治疗组患者1年的生存率(80.9%)高于对照组(75.8%)(P<0.05)。结论经皮RFA联合125I放射性粒子植入术对治疗直径>5 cm的乏血供肝恶性肿瘤有较好的临床疗效,可以提高客观缓解率和疾病控制率,延长患者的近中期生存时间。
Objective To evaluate the clinical effect of radiofrequency ablation(RFA)combined with 125I radioactive seed implantation in treating poor blood supply hepatic malignant tumors with diameter greater than 5 cm.Methods The clinical data of 80 patients with poor blood supply hepatic malignant tumor,who received minimally-invasive interventional therapy from January 2013 to June 2016,were retrospectively analyzed.According to the therapeutic method,the patients were divided into the combination group(n=47,receiving RFA plus 125I radioactive seed implantation)and thecontrol group(n=33,receiving simple transcatheter arterial chemoembolization).The curative effect,overall survival(OS)and adverse reactions were compared between the two groups.Results The objective remission rate(ORR)and the disease control rate(DCR)in the combination group were 87.2%and 95.7%respectively,which were remarkably higher than 66.7%and 81.8%respectively in the control group,the differences were statistically significant(P<0.05).The one-year survival rate in the combination group was 80.9%,which was significantly higher than 75.8%in the control group(P<0.05).Conclusion For the treatment of poor blood supply hepatic malignant tumors with diameter greater than 5 cm,RFA combined with 125I radioactive seed implantation has a good clinical effect.It can improve the ORR and the DCR,and prolong the patient’s short-term and mid-term survival time.
作者
王舒婷
陈海波
施昌盛
施振静
虞希祥
孙志超
WANG Shuting;CHEN Haibo;SHI Changsheng;SHI Zhenjing;YU Xixiang;SUN Zhichao(Interventional Ward,Department of Medical Imaging,First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang Province 310006,China)
出处
《介入放射学杂志》
CSCD
北大核心
2020年第6期587-590,共4页
Journal of Interventional Radiology
基金
浙江省医药卫生科技计划项目面上项目(2019KY663、2020KY297、2020KY671)
浙江省中医药科技计划项目(2020ZB091)
浙江省瑞安市科技计划项目(YY2014017)。
关键词
肝恶性肿瘤
经皮射频消融
125I放射性粒子植入术
微创治疗
hepatic malignant tumor
percutaneous radiofrequency ablation
125I radioactive seed implantation
minimally-invasive treatment
