摘要
目的:探讨磁振磁电治疗仪联合前列倍喜胶囊治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)的有效性及安全性。方法:采用前瞻性、双中心、随机、开放、阳性药物加载、平行对照的临床设计。将124例已确诊为CP/CPPS患者按数字表法随机分为对照组和观察组,每组62例,对照组服用前列倍喜胶囊,观察组在服用前列倍喜胶囊基础上联合磁振磁电治疗仪理疗,疗程14 d。治疗14 d结束后,比较两组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分及两组治疗总有效率;评估两组有效性和安全性。结果:两组治疗后的疼痛症状评分、排尿症状评分、生活质量评分及NIH-CPSI总评分均较治疗前明显改善(P<0.05);治疗后观察组的疼痛症状评分(7.34±3.26 vs 9.50±2.47)分、排尿症状评分(3.53±2.56 vs 4.50±2.35)分、生活质量评分(5.94±2.89 vs 8.03±2.60)分及总评分(16.65±7.90 vs 21.95±5.70)分均显著低于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为83.87%,明显高于对照组的53.23%,差异有统计学意义(P<0.05);治疗期间两组患者均无不良事件及不良反应发生,安全性评价为Ⅰ级。结论:磁振磁电治疗仪联合前列倍喜胶囊能显著缓解CP/CPPS患者的临床症状,疗效确切且安全性高,同时缩短治疗时间。
Objective: To evaluate the effect and safety of the magnetic resonance electromagnetic therapy(MREM) combined with Qianlie Beixi Capsules(QBC) in the treatment of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS). Methods: Using a prospective, two-center, randomized, open, positive drug-loading, parallel-controlled clinical design, we randomly divided 124 patients with CP/CPPS into a control and an observation group of equal number, the former treated with QBC and the latter with QBC combined with MREM for a course of 14 days. Then, we compared the NIH-CPSI scores before and after treatment, the total effectiveness rate and safety between the two groups of patients. Results: After treatment, the patients in both the observation and control groups showed significantly improved total and specific item scores on NIH-CPSI(P < 0.05), and those of the observation group achieved even more significant improvement than the controls either in the total NIH-CPSI score(16.65 ± 7.90 vs 21.95 ± 5.70, P < 0.05) or in the pain symptom score(7.34 ± 3.26 vs 9.50 ± 2.47, P < 0.05), urination symptom score(3.53 ± 2.56 vs 4.50 ± 2.35, P < 0.05) and quality of life score(5.94 ± 2.89 vs 8.03 ± 2.60, P < 0.05). The total effectiveness rate was remarkably higher in the observation than in the control group(83.87% vs 53.23%, P < 0.05). No adverse events or reactions were observed in either group of the patients during the trial. Conclusion: Magnetic resonance electromagnetic therapy combined with Qianlie Beixi Capsules can significantly relieve the clinical symptoms of CP/CPPS patients with high effectiveness and safety.
作者
何伟
孙自学
王光策
HE Wei;SUN Zi-xue;WANG Guang-ce(Department of Urology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China;Department of Reproductive Medicine,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450000,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2020年第5期452-456,共5页
National Journal of Andrology
基金
河南省高校重点科研项目计划(18A32001)。
关键词
慢性前列腺炎/慢性骨盆疼痛综合征
磁振磁电治疗仪
前列倍喜
美国国立卫生研究院慢性前列腺炎症状指数
chronic prostatitis/chronic pelvic pain syndrome
magnetic resonance electromagnetic therapy
Qianlie Beixi Capsules
National Institute of Health Chronic Prostatitis Symptom Index
