摘要
神经胶质瘤是最常见的原发性颅内肿瘤,其本质上是一种多基因异常疾病。长非编码RNA(lncRNA)是一类长度超过200个核苷酸的非编码基因,通过调控肿瘤相关基因的表达或相关信号通路在肿瘤的发生发展中发挥着重要作用。lncRNA在神经胶质瘤中异常表达有助于神经胶质瘤表型的多样性。深入研究异常表达的lncRNA在神经胶质瘤发病机制和病理分级中的潜在作用,有望为临床靶向治疗神经胶质瘤提供新的思路。
Glioma is the most common primary intracranial tumor which is essentially a polygenic abnormal disease.Long non-coding RNA(lncRNA)is a class of noncoding genes with a length of more than 200 nucleotides.LncRNA plays an important role in tumorigenesis and development by regulating the expression of tumor-related genes or related signaling pathways.The abnormally expressions of lncRNA in gliomas contribute to the diversity of glioma phenotypes.In-depth study of the potential role of abnormally expressed lncRNA in the pathogenesis and pathological grading of gliomas will provide new ideas for clinical targeted treatment of gliomas.
作者
南阳
钟跃
Nan Yang;Zhong Yue(Department of Neurosurgery,Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《国际肿瘤学杂志》
CAS
2020年第2期98-102,共5页
Journal of International Oncology
基金
天津市自然科学基金(18JCZDJC98600)。
