摘要
酒精性肝病(ALD)是一个全球性健康问题。长期饮酒会导致脂肪肝和炎症,进而可能发展为肝纤维化、肝硬化或肝癌。目前其机制尚不完全清楚,并且缺乏有效治疗药物。越来越多的证据表明,微小RNA(miRNA,miR)在ALD不同阶段都发挥了重要作用。现就近年来多种miRNAs在ALD不同阶段中的作用的研究进展进行综述,并对miRNA在ALD中的应用前景进行展望。
Alcoholic liver disease(ALD)is a major health problem globally.Long-term drinking can lead to fatty liver and inflammation,which in turn may cause liver fibrosis,cirrhosis or liver cancer.At present,the potential mechanism is not fully understood,and growing evidence shows that microRNAs(miRNAs,miR)play an important role in different stages of ALD.In this paper,the research progress in the role of various miRNAs in different stages of ALD is reviewed,and their application in ALD is prospected.
作者
吴展
钟伏弟
袁观斗
何松青
Wu Zhan;Zhong Fudi;Yuan Guandou;He Songqing(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2020年第1期194-198,共5页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(81771674、81660103)
高等学校学科创新引智计划(D17011)。
