摘要
目的运用代谢组学研究方法研究绝经后骨质疏松症常见实性证素与对照组之间的差异代谢物,并筛选绝经后骨质疏松症的潜在生物学标志物。方法通过证候辨证素量表测定绝经后骨质疏松症常见证素,每组30例,并选取正常人群对照组,运用核磁共振氢谱(HNMR)技术分析其血清的差异代谢物。结果绝经后骨质疏松症各组与正常对照组之间存在明显的差异代谢物。结论绝经后骨质疏松症各组可区分并且存在较为明显的潜在生物学标志物为甲酸,为临床治疗以及防治绝经后骨质疏松症提供了生物学依据。
Objective Metabolomics was used to study the diff erence of metabolites between the common solid syndrome elements of postmenopausal osteoporosis and the control group,and to screen the potential biomarkers of postmenopausal osteoporosis.Methods The common syndromes of postmenopausal osteoporosis were determined by syndrome differentiation factor scale,30 cases in each group,and the control group was selected.The serum differential metabolites were analyzed by nuclear magnetic resonance hydrogen spectroscopy(HNMR).Results There were signifi cant diff erences in metabolites between the postmenopausal osteoporosis groups and the normal control group.Conclusion Postmenopausal osteoporosis groups can be distinguished and there are obvious potential biological markers for formic acid,which provides biological basis for clinical treatment and prevention and treatment of postmenopausal osteoporosis.
作者
李肖飞
徐琬梨
LI Xiaofei;XU Wanli(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《吉林中医药》
2020年第5期620-624,共5页
Jilin Journal of Chinese Medicine
基金
国家自然科学基金青年基金(81503500)
山东省自然科学基金青年基金(ZR2014HQ)。
关键词
绝经后骨质疏松症
代谢组学
证素
postmenopausal osteoporosis
metabonomics
syndrome element
