摘要
目的分析新型冠状病毒肺炎(COVID-19)患者的临床特征和治疗效果。方法以2020年1月3日—3月4日湖北省武汉、广西南宁、广西柳州3家定点医院收治的193例COVID-19患者为研究对象,均于入院第1天采集病史、辅助检查等病例资料,并对所收集的资料进行描述性分析。结果(1)一般情况:193例COVID-19患者男性居多,男女比为1.4∶1,年龄3个月~95岁,平均(48.1±18.5)岁。临床分型:轻型48例(24.9%),普通型122例(63.2%),重型18例(9.3%),危重型5例(2.6%)。(2)流行病学:有武汉及其周边地区接触史130例(67.4%),有到过武汉及其周边地区人员接触史18例(9.3%)。(3)基础疾病:以高血压(11.4%)和糖尿病(3.6%)较常见。(4)临床症状:患者以发热(57.0%)和咳嗽(42.0%)为主要临床表现。(5)实验室检查:白细胞数正常或降低188例(97.4%),淋巴细胞降低49例(25.4%),ALT和/或AST升高47例(24.4%),高敏C反应蛋白升高30例(15.5%),中性粒细胞百分比升高22例(11.4%)。(6)CT检查:患者肺部病灶累及双肺109例(56.5%),累及单肺7例(3.6%),CT无异常77例(39.9%);病灶特征包括磨玻璃样变103例(53.4%),实变64例(33.2%),空气支气管征43例(22.3%)和铺路石征16例(8.3%)。(7)治疗及转归:主要的治疗方案为抗病毒、中医中药及营养支持等对症治疗,好转或治愈率为97.4%,病死率2.6%。结论COVID-19患者以男性较多,临床分型以轻型及普通型为主;大多数患者有疫区或到过疫区人员接触史;基础疾病以高血压和糖尿病较常见;最常见的症状为发热和咳嗽,多数患者白细胞正常或降低,部分患者淋巴细胞降低,多数患者病灶累及双肺,磨玻璃样变和实变是最常见的病灶特征;COVID-19患者应用抗病毒、中医中药及营养支持等对症治疗的疗效较好。
Objective To analyze coronavirus disease 2019(COVID-19)patients'clinical characteristics and therapeutic effect.Methods From January 3 to March 4,2020,193 patients with COVID-19 who were admitted to three designated hospitals in Wuhan(Hubei Province),Nanning and Liuzhou of Guangxi Province were taken as the research objects.The data of medical history,auxiliary examination and other cases were collected on the first day of admission,and the collected data were analyzed descriptive.Results(1)General information:193 patients with COVID-19 were mostly male,the ratio of male to female was 1.4∶1,the age ranged from 3 months to 95 years,the average age was(48.1±18.5)years.Clinical classification:48 cases of light type(24.9%),122 cases of common type(63.2%),18 cases of heavy type(9.3%),5 cases of severe type(2.6%).(2)Epidemiology:130 cases(67.4%)had contact history in Wuhan and its surrounding areas,and 18 cases(9.3%)had contact history in Wuhan and its surrounding areas.(3)Basic diseases:hypertension(11.4%)and diabetes(3.6%)were common.(4)Clinical symptoms:fever(57.0%)and cough(42.0%)were the main clinical manifestations.(5)Laboratory examination showed that 188 cases(97.4%)had normal or decreased leukocyte count,49 cases(25.4%)had decreased lymphocyte count,47 cases(24.4%)had increased ALT and/or AST,30 cases(15.5%)had increased high-sensitivity C-reactive protein,and 22 cases(11.4%)had increased neutrophil percentage.(6)CT examination:109 cases(56.5%)of double lung,7 cases(3.6%)of single lung and 77 cases(39.9%)of normal CT were involved in the lesions.The features of the lesions included ground glass degeneration in 103 cases(53.4%),consolidation in 64 cases(33.2%),air bronchogram in 43 cases(22.3%)and paving stone in 16 cases(8.3%).(7)Treatment and outcome:the main treatment is antiviral,traditional Chinese medicine and nutritional support.The improvement or cure rate is 97.4%,and the mortality is 2.6%.Conclusion The majority of patients with COVID-19 are male,and the clinical types are light and common;most of them have contact history with people in the epidemic area or who have been to the epidemic area;hypertension and diabetes are common basic diseases;the most common symptoms are fever and cough,most of them have normal or low white blood cells,some of them have low lymphocytes,most of them have double lungs,Ground glass and consolidation are the most common features of lesions,and COVID-19 patients have better therapeutic effect on symptoms with antiviral,traditional Chinese medicine and nutritional support.
作者
钟枝梅
宾雁飞
朱洁云
吉攀
谢周华
王晓源
张剑锋
郑晓文
罗杰峰
Zhong Zhimei;Bin Yanfei;Zhu Jieyun;Ji Pan;Xie Zhouhua;Wang Xiaoyuan;Zhang Jianfeng;Zheng Xiaowen;Luo Jiefeng(Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China;不详)
出处
《疑难病杂志》
CAS
2020年第6期559-562,共4页
Chinese Journal of Difficult and Complicated Cases
基金
国家自然科学基金资助项目(81960343)
广西重点研发计划防控新型冠状病毒感染肺炎疫情应急科技攻关专项(AB20058002)
广西医学高层次骨干人才培养‘139’计划(G201903027)。
关键词
新型冠状病毒肺炎
流行病学
临床特征
治疗效果
Coronavirus disease 2019
Epidemiology
Clinical characteristics
Treatment effects
