摘要
在中医临床中,半夏是一种常用的中药材,具有非常重要的药用价值,但其生品具有一定毒性。根据中医药基础理论,半夏经炮制后可以降低其毒副作用,从而保证临床安全用药。该文基于半夏复制法的炮制特点,探讨半夏多物料多流程炮制前后变化。该法没有统一工序,加入一种或多种物料,按不同流程,如浸、泡、漂,或蒸、煮,或数法共用,反复炮制达到规定的质量要求。通过不同炮制方法,其功效等也随之变化,用于不同疾病的治疗。文章从多物料,多流程2个方向出发,分别综述了多物料或多流程炮制对其化学成分、药效的影响,以及减毒增效的炮制机制,以期为半夏降低毒性增强疗效,扩大药用范围提供参考,为后人进一步研究炮制机制提供理论依据。对半夏的深入性研究,使得半夏更加安全有效地应用于临床,以确保临床疗效。为今后对半夏饮片炮制的质量控制、有效成分以及新药研发方面的研究提供参考。对其寻求最佳的炮制工艺奠定了科学基础,为解决半夏炮制品存在的生产问题提供理论依据,从而达到提高生产效率,提高药品质量的目的。
In the clinical practice of traditional Chinese medicine,Pinelliae Rhizoma is a commonly used traditional Chinese medicinal material,with a very important medicinal value,but its raw products have certain toxicity.According to the basic theory of traditional Chinese medicine,after Pinelliae Rhizoma is processed,its toxic and side effects can be reduced,there by ensuring its medication safety in clinic.Based on the processing characteristics of Pinelliae Rhizoma replication method,this article discusses the changes before and after processing of Pinelliae Rhizoma with multiple materials and multiple processes.This method does not have a unified process.One or more materials are added,and various processes,such as dipping,soaking,bleaching,or steaming,cooking or combined methods are adopted.Then,Pinelliae Rhizoma is repeatedly processed to meet the specified quality requirements.By different processing methods,the efficacy changes accordingly,and Pinelliae Rhizoma can be used for the treatment of different diseases.The article starts in the two directions of multi-materials and multi-processes,and summarizes the effects of multi-materials or multi-processes on the chemical composition and efficacy,as well as the processing mechanism of reducing toxicity and increasing efficiency,in the expectation of reducing the toxicity and enhancing the efficacy of Pinelliae Rhizoma.The medicinal scope provides a reference and theoretical basis for further studies on the processing mechanism.An in-depth study is conducted to make Pinelliae Rhizoma more safe and effective in clinic application,and ensure its clinical efficacy.It will provide reference for future studies on quality control,active ingredients and new drug development of the processing of pinellia slices.It has laid a scientific foundation for exploring the best processing techno-logy,and provided a theoretical basis for solving the production problems of processed Pinelliae Rhizoma products,so as to improve the production efficiency and the quality of medicines.
作者
崔美娜
钟凌云
张大永
杨明
CUI Mei-na;ZHONG Ling-yun;ZHANG Da-yong;YANG Ming(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Sichuan Neautus Traditional Chinese Herb Limited Company,Sichuan 611731,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第6期1304-1310,共7页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2018YFC1707200)。
关键词
半夏
多物料
多流程
炮制方法
临床
药效
Pinelliae Rhizoma
multi-material
multi-process
processing method
clinical
medicinal effect
