摘要
目的探讨新辅助化学治疗联合宫颈癌根治术治疗宫颈癌的临床效果。方法选择2013年1月至2016年12月周口市中心医院收治的68例宫颈癌患者作为研究对象,按照治疗方法将患者分为观察组和对照组,每组34例。观察组患者给予术前新辅助化学治疗联合宫颈癌根治术,对照组患者给予单纯宫颈癌根治术;新辅助化学治疗疗程结束后采用世界卫生组织制定的实体瘤疗效评价标准评价观察组患者治疗效果,治疗后对2组患者手术时间、术中出血量、术后住院时间及术后病理检查结果进行比较。结果观察组34例患者,新辅助化学治疗完全缓解10例,部分缓解18例,疾病稳定6例,总有效率为82.35%(28/34)。观察组患者手术时间和术后住院时间显著短于对照组(P<0.05),观察组患者术中出血量显著少于对照组(P<0.05)。观察组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率、宫旁浸润率分别为8.82%(3/34)、0.00%(0/34)、29.41%(10/34)、11.76%(4/34),对照组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率、宫旁浸润率分别为29.41%(10/34)、11.76%(4/34)、52.94%(18/34)、8.82%(3/34),观察组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率显著低于对照组(P<0.05),2组患者宫旁浸润率比较差异无统计学意义(P>0.05)。结论术前新辅助化学治疗疗效确切,可以显著缩短宫颈癌根治术手术时间和患者术后住院时间,减少术中出血量,降低术后盆腔淋巴结转移、切缘阳性和宫颈深肌层浸润率。
Objective To investigate the clinical effect of preoperative neoadjuvant chemotherapy combined with radical resection in the treatment of cervical cancer.Methods A total of 68 patients with cervical cancer admitted to Zhoukou Central Hospital from January 2013 to December 2016 were selected as the study objects,and the patients were divided into observation group and control group according to the treatment methods,with 34 cases in each group.The patients in the observation group were given preoperative neoadjuvant chemotherapy combined with radical operation of cervical cancer,while the patients in the control group were given radical operation of cervical cancer.The therapeutic effect of the patients in the observation group was evaluated by the response evaluation criteria in solid tumors formulated by the World Health Organization after new adjuvant chemotherapy.The operation time,intraoperative bleeding volume,postoperative hospitalization time and the results of postoperative pathological examination were compared between the two groups after treatment.Results A total of 34 patients in the observation group were treated with neoadjuvant chemotherapy,there were 10 cases of complete remission,18 cases of partial remission and 6 cases of stable disease;the total effective rate was 82.35%(28/34).The operation time and postoperative hospitalization time of patients in the observation group were significantly shorter than those in the control group(P<0.05),and the intraoperative bleeding volume of patients in the observation group was significantly less than that in the control group(P<0.05).In the observation group,the pelvic lymph node metastasis rate,the positive rate of incision margin,the infiltration rate of cervical deep myometrium and the infiltration rate of parauterine tissues were 8.82%(3/34),0.00%(0/34),29.41%(10/34)and 11.76%(4/34);and they were 29.41%(10/34),11.76%(4/34),52.94%(18/34)and 8.82%(3/34)in the control group.The pelvic lymph node metastasis rate,the positive rate of incision margin and the infiltration rate of cervical deep myometrium in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the infiltration rate of parauterine tissues between the two groups(P>0.05).Conclusion Preoperative neoadjuvant chemotherapy has the definite effect,which can significantly shorten the operation time and postoperative hospitalization time,reduce the intraoperative bleeding volume,the postoperative pelvic lymph node metastasis rate,the positive rate of incision margin and the infiltration rate of cervical deep myometrium in patients with cervical cancer.
作者
于鹤
刘光新
YU He;LIU Guangxin(Department of Gynecology,Zhoukou Central Hospital,Zhoukou 466000,Henan Province,China)
出处
《新乡医学院学报》
CAS
2020年第4期359-361,366,共4页
Journal of Xinxiang Medical University
关键词
宫颈癌
新辅助化学治疗
宫颈癌根治术
cervical cancer
neoadjuvant chemotherapy
radical resection for cervical cancer
