摘要
目的 探讨玻璃酸钠注射结合乙哌立松治疗膝骨关节炎的临床效果。方法 94例膝骨关节炎患者,按照随机数字法将其分为对照组与实验组,每组47例。对照组患者使用玻璃酸钠进行治疗,实验组患者使用玻璃酸钠注射结合乙哌立松进行治疗。比较两组患者治疗前后尿液中CTX-Ⅱ含量、疼痛评分、膝关节功能评分、生活质量评分。结果 治疗后,实验组尿液中CTX-Ⅱ含量(236.78±26.59)ng/mmol低于对照组的(364.45±41.23)ng/mmol,差异具有统计学意义(P<0.05)。实验组疼痛评分(3.01±0.89)分低于对照组的(4.46±1.68)分,差异具有统计学意义(P<0.05)。实验组膝关节功能评分(84.45±11.68)分高于对照组的(75.89±11.84)分,差异具有统计学意义(P<0.05)。实验组物质生活、社会角色、心理健康、躯体健康评分分别为(86.23±1.89)、(87.43±2.13)、(87.52±3.01)、(88.23±4.13)分,均高于对照组的(76.02±4.31)、(79.23±4.56)、(79.01±4.89)、(77.25±4.89)分,差异具有统计学意义(P<0.05)。结论 玻璃酸钠注射结合乙哌立松治疗膝骨关节炎的临床效果显著。
Objective To discuss the clinical effect of sodium hyaluronate injection combined with eperisone in the treatment of knee osteoarthritis.Methods A total of 94 patients with knee osteoarthritis were divided into control group and experimental group by random number table method,with 47 cases in each group.The control group was treated by sodium hyaluronate,and the experimental group was treated by sodium hyaluronate injection combined with eperisone.The content of CTX-Ⅱin urine,pain score,knee joint function score and quality of life score before and after treatment were compared between the two groups.Results After treatment,the CTX-Ⅱin urine(236.78±26.59)ng/mmol in the experimental group was lower than(364.45±41.23)ng/mmol in the control group,and the difference was statistically significant(P<0.05).The pain score(3.01±0.89)points in the experimental group was lower than(4.46±1.68)points in the control group,and the difference was statistically significant(P<0.05).The knee joint function score(84.45±11.68)points in the experimental group was higher(75.89±11.84)points in the control group,and the difference was statistically significant(P<0.05).The material life,social role,mental health,physical health scores were(86.23±1.89),(87.43±2.13),(87.52±3.01)and(88.23±4.13)points in the experimental group,which were higher than(76.02±4.31),(79.23±4.56),(79.01±4.89)and(77.25±4.89)points in the control group,and their difference was statistically significant(P<0.05).Conclusion Sodium hyaluronate injection combined with eperisone shows remarkable clinical effect in the treatment of knee osteoarthritis.
作者
熊伟
李宝军
XIONG Wei;LI Bao-jun(Department of Orthopedics,Hunan Second People’s Hospital,Changsha 410007,China)
出处
《中国现代药物应用》
2020年第10期14-16,共3页
Chinese Journal of Modern Drug Application
关键词
玻璃酸钠
乙哌立松
膝骨关节炎
临床效果
Sodium hyaluronate
Eperisone
Knee osteoarthritis
Clinical effect
