摘要
目的探索乳腺浸润性导管癌及导管原位癌超声表现与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(Her-2)、增殖指数Ki-67表达的关系。方法收集山西省肿瘤医院2017年8月至2018年10月手术治疗的乳腺癌患者225例,术前进行超声检查并详细记录乳腺肿物的超声特征:大小、边界、形态、内部回声、后方回声衰减、微钙化。术后行石蜡病理组织学诊断及检测ER、PR、Her-2表达、Ki-67表达,分析浸润性导管癌和导管原位癌的超声特点与ER、PR、Her-2表达、Ki-67表达之间关系。结果不同的PR组间微钙化发生率差异有统计学意义(P<0.05),PR阴性组更多出现微钙化;ER、PR、Her-2、Ki-67不同组的其他超声特点差异无统计学意义;浸润性导管癌和导管原位癌组的Ki-67阳性率差异有统计学意义(P<0.05),浸润性导管癌组的Ki-67阳性率高于导管原位癌组。结论乳腺癌超声特点与ER、PR、Her-2、Ki-67表达之间有一定联系,对判断乳腺癌分子亚型和预后有诊断价值。
Objective To investigate the relationship between the ultrasound characteristics and expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(Her-2)and Ki-67 in invasive ductal carcinoma and ductal carcinoma in situ of the breast.Methods Included in this study were 225 breast cancer patients who underwent surgery in Shanxi Cancer Hospital between August 2017 and October 2018.Preoperative ultrasound examination was carried out and the ultrasonic characteristics of breast tumors were recorded with regards to tumor size,boundary,shape,internal echo,posterior echo attenuation,and microcalcification.After surgery,the histological diagnosis,as well as expression of ER,PR,Her-2 and Ki-67,was determined by pathologists based on study of paraffin-embedded specimens.SPSS 17.0 statistical software was used to analyze the relationship between the ultrasound characteristics and expression of ER,PR,Her-2 and Ki-67 in invasive ductal carcinoma and ductal carcinoma in situ of the breast(P<0.05).Results There was a significant differences in microcalcification be-tween PR positive and negative PR groups(P<0.05),which was more likely to occur in the PR negative group.There was no significant difference in other ultrasound characteristics between groups testing negative and positive for ER,PR,Her-2,and Ki-67.There was a difference in Ki-67 positivity between invasive ductal carcinoma and ductal carci-noma in situ of the breast(P<0.05),with was more frequent in invasive ductal carcinoma compared with ductal carci-noma in situ.Conclusion Certain correlation exists between the ultrasound characteristics and expression of ER,PR,Her-2,and Ki-67 in breast cancer.Ultrasound patterns may be of diagnostic value for molecular subtyping and prog-nosis evaluation of breast cancer.
作者
郭荣荣
梁新星
范彦芳
薛改琴
Guo Rongrong;Liang Xinxing;Fan Yanfang;Xue Gaiqin(Department of Ultrasound,Shanxi Cancer Hospital,Taiyuan 030013,China)
出处
《中国药物与临床》
CAS
2020年第9期1439-1441,共3页
Chinese Remedies & Clinics
基金
山西省回国留学人员科研资助项目(2017-127)
山西省留学回国人员科技活动择优资助项目(山西省人力资源和社会保障厅)。
关键词
乳腺肿瘤
超声检查
免疫组织化学
Breast neoplasms
Ultrasonography
Immunohistochemistry
