摘要
目的 探讨乳腺浸润性导管癌与导管内癌的超声造影表现与癌基因C-erbB-2、Ki-67表达的相关性.方法 回顾性分析29例乳腺浸润性导管癌和12例乳腺导管内癌患者的超声造影特征及定量分析,所有病例均经手术或穿刺病理确诊,术后对肿瘤标本用免疫组化方法测定C-erbB-2、Ki 67表达情况,并分析其与超声造影表现之间的关系.结果 29例乳腺浸润性导管癌肿块Ki-67表达阳性率68.97％（20/29）,C-erbB-2表达阳性率48.2％ （14/29）;12例导管内癌肿块Ki-67表达阳性率16.67％（2/12）,C-erbB-2表达阳性率42.6％（5/12）.乳腺浸润性导管癌与导管内癌肿块均以高增强为主,与C-erbB-2表达相关性不明显.乳腺浸润性导管癌Ki-67阳性表达率明显高于导管内癌,超声造影表现出现灌注缺损与Ki-67表达阳性有相关性.结论 乳腺浸润性导管癌与导管内癌在超声造影肿瘤微血管灌注特点上与分子生物学指标Ki-67蛋白之间存在一定的相关性.
Objective To evaluate the relation of appearance of contrast-enhanced ultrasonography （CEUS） to Ki 67 and C-erbB-2 in breast invasive ductal carcinoma and ductal carcinoma in situ.Methods The appearance of CEUS in 29 patients with breast invasive ductal carcinoma and 12 patients with ductal carcinoma in situ,which was diagnosed by surgery or biopsy,was analysed retrospectively.The Ki-67 and CerbB-2 were measured by immunohistochemical test.The relation of the above two factors to appearance of contrast ultrasonography was analysed.Results The positive rate of Ki-67 was 68.97％ （20/29） in patients with breast invasive ductal carcinoma and 16.67％ （2/12） in patients with ductal carcinoma in situ.The positive rate of C-erbB-2 was 48.2％ （14/29） in patients with breast invasive ductal carcinoma and 42.6％ （5/12） in patients with ductal carcinoma in situ.The masses had a common appearance of high enhance in patients with breast invasive ductal carcinoma and ductal carcinoma in situ,which was not correlated to C-erbB-2.The Ki-67 was significantly higher in patients with ductal carcinoma in situ than that in patients with breast invasive ductal carcinoma,the appearance of CEUS was correlated to Ki 67.Conclusions The features of micro-vessels by CEUS were correlated to Ki-67 in patients with breast invasive ductal carcinoma and ductal carcinoma in situ.
出处
《中华超声影像学杂志》
CSCD
北大核心
2014年第12期1061-1064,共4页
Chinese Journal of Ultrasonography
