摘要
目的:观察扶正健脾方减轻Ⅲ、Ⅳ期儿童神经母细胞瘤化疗不良反应的临床效果。方法:采用前瞻性设计,将神经母细胞瘤患儿100例随机分为观察组和对照组各50例。对照组单纯采用化疗,观察组在化疗基础上口服扶正健脾方;3个月后评估相关情况。结果:观察组化疗不良反应(主要为骨髓抑制及消化道反应)低于对照组,化疗完成情况(包括住院天数、化疗延期天数)优于对照组,且化疗期间辅助用药情况(主要为应用粒细胞集落刺激因子及输注悬浮红细胞情况)优于对照组,差异均有统计学意义(P<0.05)。结论:扶正健脾方能降低Ⅲ、Ⅳ期神经母细胞瘤患儿化疗不良反应,减少化疗辅助用药,有助于化疗顺利完成。
Objective: To observe clinical effects of body resistance-strengthening spleen-invigorating prescription in the treatment of chemotherapy-induced adverse reaction in children with stage Ⅲ and Ⅳ neuroblastoma.Methods: By conducting the prospective cohort study, the children were randomized into the observation group and the control group, 50 cases each group. The control group accepted chemotherapy, and the observation group took body resistance-strengthening spleen-invigorating prescription on the foundation of chemotherapy;to assess the related conditions in three months. Results: The observation group was lower than the control group in chemotherapyinduced adverse reactions(mainly bone marrow suppression and gastrointestinal reaction), superior to the control group in the completion of chemotherapy(including hospitalization days and delay days of chemotherapy), in the conditions of adjuvant drugs during the chemotherapy period(mainly the application of granulocyte colony-stimulating factor G-CSF and the infusion of suspended red blood cells) and the difference showed statistical meaning(P<0.05).Conclusion: Body resistance-strengthening spleen-invigorating prescription could reduce chemotherapy-induced adverse reaction in children with stage Ⅲ and Ⅳ neuroblastoma, reduce chemotherapy adjuvant medication and it is helpful to finish the chemotherapy smoothly.
作者
黄静
史学
马晓莉
刘畅
赵文
HUANG Jing;SHI Xue;MA Xiaoli;LIU Chang;ZHAO Wen(National Center for Children's Health,Beijing Children’s Hospital,Capital Medical University,Beijing 100045,China)
出处
《西部中医药》
2020年第3期87-89,共3页
Western Journal of Traditional Chinese Medicine
基金
北京市中医药科技发展资金项目(JJ2015-27)。
关键词
神经母细胞瘤
化疗
扶正健脾方
儿童
neuroblastoma
chemotherapy
body resistance-strengthening spleen-invigorating prescription
children
