摘要
目的研究急性ST段抬高型心肌梗死(STEMI)患者血清高敏肌钙蛋白T(hs-cTnT)水平与冠状动脉(冠脉)病变及心功能的相关性。方法自2018年8月至2019年5月于徐州医科大学附属医院心血管内科,确诊STEMI患者的165例,行急诊经皮冠脉介入术(PCI)118例,择期PCI47例,规律监测其hs-cTnT水平,按照中位数法分为低、高水平组。Gensini评分用于评价冠脉病变程度,N末端脑钠肽前体(NT-proBNP)及心脏彩超评估心功能。结果低hs-cTnT水平组与高hs-cTnT水平组相比,Gensini评分较低,而左室射血分数(LVEF)值较高,差异有统计学意义(P<0.05);三支病变组的hs-cTnT、Gensini评分水平明显高于单支、双支(P<0.05)病变组。双支、三支病变组的NT-proBNP明显高于单支病变组(P<0.05)。三支病变组的LVEF明显低于单支病变及双支病变组(P<0.05)。Gensini评分、左室舒张末内径(LVEDd)和hs-cTnT之间为正相关(P<0.05);LVEF和hs-cTnT之间呈现负相关(P<0.01)。结论STEMI患者的hs-cTnT水平与冠状动脉病变及心功能关系密切,hs-cTnT水平越高,冠状动脉病变越重,心功能越差。
Objective To investigate the relationship between high-sensitivity troponin T(hs-cTnT)level and coronary artery lesion and cardiac function in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods 1From August 2018 to May 2019,in the Department of Cardiovascular Medicine,Affiliated Hospital of Xuzhou Medical University,165 patients with STEMI were diagnosed,118 patients underwent emergency percutaneous coronary intervention(PCI),and 47 patients underwent elective PCI.The hs-cTnT level was monitored and divided into low and high level groups according to the median method.Gensini score is used to evaluate the degree of coronary artery disease,N-terminal brain-type natriuretic peptide(NT-proBNP)and cardiac color Doppler ultrasound to evaluate cardiac function.Results Compared with the high hs-cTnT level group,the low hs-cTnT level group had a lower Gensini score and a higher left ventricular ejection fraction(LVEF)value,and the difference was statistically significant(P<0.05).;Hs-cTnT and Gensini scores were significantly higher in the three-vessel disease group than in the single-branch and double-branch disease group(P<0.05).NT-proBNP was significantly higher in the two-and three-vessel disease group than in the single-vessel disease group(P<0.05).The LVEF of the three-vessel disease group was significantly lower than that of the single-vessel disease and double-vessel disease group(P<0.05).Gensini score,left ventricular end-diastolic diameter(LVEDd)and hs-cTnT were positively correlated(P<0.05);LVEF and hs-cTnT were negatively correlated(P<0.01).Conclusion The level of hs-cTnT in STEMI patients is closely related to coronary artery lesion and cardiac function.The higher the level of hs-cTnT,the heavier the coronary lesions and the worse the cardiac function.
作者
谭梦彤
纵静
李芳芳
徐路红
钱文浩
Tan Mengtong;Zong Jing;Li Fangfang;Xu Luhong;Qian Wenhao(Graduate School,Xuzhou Medical University,Xuzhou 221002,China)
出处
《中国循证心血管医学杂志》
2020年第4期460-463,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
