摘要
目的探讨血清中胰岛素抵抗与内分泌激素对多囊卵巢综合征(PCOS)患者的影响。方法1917例经临床确诊的PCOS患者为观察组,1948例健康育龄期妇女为对照组,采用化学发光分析仪测定血清中性激素相关指标[血清雌二醇(E2)、孕酮(P)、睾酮(T)、催乳素(PRL)、黄体生成素(LH)、促卵泡激素(FSH)];采用电化学发光分析仪测定空腹血清胰岛素(INS)水平;采用全自动生化分析仪测定血清中空腹血糖(GLU)浓度,并计算稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(HOMA-ISI)等。结果与对照组比较,观察组血清T、LH、GLU、INS、HOMA-IR、LH/FSH显著上升,HOMA-ISI、E/T显著下降,差异均有统计学意义(P<0.05);经过多元回归后分析:PCOS患者血清中HOMA-IR水平与T、LH、GLU、INS呈正相关(r值分别为0.335、0.339、0.343、0.347,P<0.05),与H0MA-ISI呈负相关(r=-0.328,P<0.05)。结论PCOS患者HOMA-IR、GLU、INS明显升高、内分泌激素发生紊乱变化,提示其高水平的HOMA-IR与内分泌激素紊乱是PCOS患者发病的危险因素之一,临床诊治过程中更要关注患者的胰岛素抵抗与性激素的水平变化,并对其胰岛素抵抗与性激素紊乱采取必要的干预措施,进而防止、延缓并发症的发生。
Objective To investigate the influence of serum insulin resistance and hormone on the patients with polycystic ovary syndrome(PCOS).Methods A total of 1917 clinically diagnosed patients with PCOS were selected as the observation group,1948 healthy women in childbearing age were served as the control group.Chemiluminescence analyzer was used to determine the serum sex hormone-related indicators serum estradiol(E2),progesterone(P),testosterone(T),prolactin(PRL),luteinizing hormone(LH),follicle-stimulating hormone(FSH);fashing serum(INS)level determined by electrochemiluminescence analyzer.Automatic biochemical analyzer was used to determine the serum glucose(GLU)concentrations and calculate homeostasis model assessment of insulin resistance index(HOMA-IR),insulin sensitivity index(HOMA-ISI)and other clinical data.Results Compared to the control group,the serum T,LH,GLU,INS,HOMA-IR,LH/FSH levels of the observation group significantly increased,and the HOMA-ISI,E/T levels were significantly lower,with the differences statistically significant(P<0.05).The multiple regression analysis shows that the serum HOMA-IR level in the patients with PCOS was positively correlated with T,LH,GLU,INS(r=0.335,r=0.339,r=0.343,r=0.347,P<0.05),and negatively correlated with HOMA-ISI levels(r=-0.328,P<0.05).Conclusion The HOMA-IR,GLU,INS levels of patients with PCOS significantly increased and hormone was disordered,which indicates the high levels of HOMA-IR and hormone disorders are risk factors for the onset of PCOS patients.During clinical diagnosis and treatment process,it is suggested to pay attention to the insulin resistance and sex hormones level changes of the patient,and take the necessary interventions to their insulin resistance and hormone disorders,thus preventing and delaying the complications.
作者
王笑颜
王海燕
沈翠芬
邵圣文
谢毓芳
WANG Xiao-yan;WANG Hai-yan;SHEN Cui-fen;SHAO Sheng-wen;XIE Yu-fang(Huzhou Central Hospital,Huzhou,Zhejiang 313000,China;不详)
出处
《中国卫生检验杂志》
CAS
2020年第7期843-845,共3页
Chinese Journal of Health Laboratory Technology
关键词
多囊卵巢综合征
胰岛素抵抗
内分泌激素
Polycystic ovary syndrome
Insulin resistance
Endocrine hormones
