摘要
目的对益生菌对哮喘的预防及治疗作用进行系统评价,为临床上益生菌的合理应用提供依据。方法计算机检索中国知网、中国生物医学文献数据库、重庆维普、万方数据知识服务平台、PubMed、Embase、Cochrane Library、Web of Science等数据库建库至2019年2月的所有相关文献,并手工检索相关文献的参考文献。使用Cochrane偏倚风险评估工具对纳入研究进行评价。结果益生菌对哮喘预防作用的系统评价纳入12项研究,结果显示益生菌对哮喘(RR=0.95,95%CI=0.82~1.11)及喘息(RR=0.99,95%CI=0.88~1.11)的发生无预防作用。针对各干预细节进行亚组分析后结果无差异。益生菌对哮喘治疗作用的系统评价纳入6项研究,结果显示益生菌对哮喘患者的肺功能及哮喘控制水平有改善作用,但尚需更多研究对此进行证实;益生菌对哮喘患者的免疫学指标及哮喘药物使用等的影响尚需更多研究进行探讨。结论基于现有证据,本研究显示益生菌对哮喘及喘息的发生无预防作用;益生菌对哮喘患者的肺功能及哮喘控制水平可能有改善作用,但未来还需更多研究证实。
Objective To systematically review the effects of probiotic supplementation on the prevention and treatment of asthma.Methods A computerized literature search was conducted in CNKI,CBM,VIP,Wanfang,PubMed,Embase,Cochrane Library,and Web of Science from their inception to February,2019 to collect all relevant studies.Cochrane Collaboration’s risk of bias tool was used to assess the methodological quality of the included studies.Results Twelve studies were included in the systematic review of the value of probiotics in asthma prevention.The results showed that probiotic supplementation was not significantly associated with a lower risk of asthma(RR=0.95,95%CI=0.82-1.11)or wheeze(RR=0.99,95%CI=0.88-1.11).Subgroup analyses based on interventions did not show significant differences.Six studies were included in the systematic review of the role of probiotics in asthma treatment.The results showed that probiotic supplementation improved pulmonary function and asthma control in asthmatic patients.However,more studies are needed to validate this effect.Moreover,further studies are needed to clarify the effect of probiotics on the immune markers and the use of asthmatic drugs in asthmatic patients.Conclusions Based on the currently available literature,probiotic supplementation can not prevent asthma or wheeze.However,it may improve pulmonary function and asthma control in asthmatic patients,although further studies are needed.
作者
姜迪
白晨晓
陈欧
JIANG Di;BAI Chenxiao;CHEN Ou(Department of Community Nursing,Nursing School of Shandong University,Jinan 250012,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2020年第2期178-189,共12页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81400072)
山东省自然科学基金(ZR2013HQ047)
山东大学人文社科青年团队项目(IFYT1811、IFYT18036、IFYT18037)
山东省重点研发项目(2019GSF108198)。
关键词
益生菌
哮喘
预防
治疗
系统评价
probiotics
asthma
prevention
treatment
systematic review
