摘要
目的探讨新生儿重症溶血病患儿采用全自动换血治疗的疗效.方法回顾性分析2016年2月至2019年2月48例新生儿重症溶血病达换血指征患儿的临床资料,采取传统换血方法治疗的患儿为对照组,将采取全自动换血方法治疗的患儿为观察组.比较两组患者高胆红素血症治疗总有效率;皮肤黄疸完全消失时间、住院平均时间;坏死性小肠结肠炎、感染等并发症发生率;治疗前后直接胆红素、间接胆红素和总胆红素水平.结果观察组患者重症溶血病治疗总有效率比对照组高(P<0.05);观察组皮肤黄疸完全消失时间、住院平均时间比对照组短(P<0.05);观察组坏死性小肠结肠炎、感染等并发症发生率比对照组低(P<0.05).治疗前两组患者直接胆红素、间接胆红素和总胆红素水平差异无统计学意义(P>0.05);治疗后观察组患者直接胆红素、间接胆红素和总胆红素水平显著低于对照组(P<0.05).结论新生儿重症溶血病患儿采用全自动换血治疗的疗效明显,可有效改善患儿临床症状,缩短疗程,降低血清胆红素水平,减少坏死性小肠结肠炎、感染等并发症的发生风险,安全性提高,值得推广.
Objective To explore the therapeutic effect of automatic exchange of blood in the treatment of severe hemolytic disease of newborn.Methods The clinical data of 48 cases of severe hemolytic disease of newborn admitted to our hospital from February 2016 to February 2019 were analyzed retrospectively.The control group was the children who were treated with traditional blood exchange method,and the observation group was the children who were treated with automatic blood exchange method.The total effective rate of hyperbilirubinemia treatment,the time of complete disappearance of skin jaundice and the average time of hospitalization,the incidence of complications such as necrotizing enterocolitis and infection,the levels of direct bilirubin,indirect bilirubin and total bilirubin before and after treatment were compared.Results The total effective rate of severe hemolytic disease in the observarion group was higher than that in the control group(P<0.05),and the complete disappearance time of skin jaundice and the average hospitalization time in the observation group were shorter than those in the control group(P<0.05).The incidence of necrotizing enterocolitis and infection in the observation group was lower than that in the control group(P<0.05).There was no significant difference in the levels of direct bilirubin,indirect bilirubin and total bilirubin between the two groups before treatment(P>0.05).After treatment,the levels of direct bilirubin,indirect bilirubin and total bilirubin in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The effect ot automatic exchange of blood is obvious,which can effectively improve the clinical symptoms,shorten the course of tre?itment,reduce the level of serum bilirubin,reduce the risk of complications such as necrotizing enterocolitis and infection,and improve the safety.
出处
《浙江临床医学》
2020年第3期403-404,共2页
Zhejiang Clinical Medical Journal
关键词
新生儿
重症溶血病
全自动换血治疗
疗效
Newborn
Severe hemolysis
Automatic blood exchange therapy
Curative effect
