摘要
目的探讨全自动同步换血术在新生儿溶血病治疗中的作用。方法对27例达换血标准的新生儿溶血病患儿采用以外周动静脉作为输入、输出途径,用两部输液泵建立全自动双管末梢血管同步换血,换血前后检测患儿各项胆红素水平及血压、电解质、血糖水平。结果换血前后血清总胆红素、结合胆红素、非结合胆红素下降水平差异有统计学意义(P<0.01)。血糖及血红蛋白水平在换血后升高,差异有统计学意义(P<0.05);而血压、血钙水平在换血前后差异无统计学意义(P>0.05)。27例患儿黄疸完全消退,最早为换血后2 d,最迟13 d,平均6 d。结论全自动同步换血术可迅速降低胆红素水平,治疗新生儿溶血病的效果显著,无明显并发症;相对于传统换血术可减少感染机会,对血压影响小,适宜临床推广应用。
Objective To discuss the effect of automatic synchronous exchange transfusion in the treatment of hemolytic disease of the newborn （HDN）. Methods 27 cases with HDN met the criteria of exchange transfusion were treated via peripheral artery and vein as input and output pathways and by two infusion pumps aiming at realizing automatic syn- chronous exchange of double peripheral vessels.The levels of bilirubins,blood pressure,blood electrolytes,and blood glu- cose were tested before and after the therapy. Results The levels of serum total bilirubin,direct bilirubin,and indirect bilirubin after treatment decreased more remarkably compared with those prior treatment （P〈0.01）.After exchange trans- fusion,the levels of blood glucose and hemoglobin increased significantly in comparison with those before treatment （P〈 0.05）.There was no obvious difference in blood pressure or blood calcium before and after treatment （P〉0.05）.Jaundice in 27 cases was totally subsided ranged from 2-13 days after exchange transfusion at an average of 6 days. Conclusion The automatic synchronous exchange transfusion rapid decreases the levels of birilubins and obtains a remarkable effect on treating HDN without obvious complications.In comparison with the conventional therapy,it reduces the possibility of infection and has little influence on blood pressure,which is worthy of expansion in clinic.
出处
《中国当代医药》
2014年第2期35-37,共3页
China Modern Medicine
关键词
全自动同步换血术
新生儿溶血病
临床分析
Automatic synchronous exchange transfusion
Hemolytic disease of the newborn （HDN）
Clinical analysis
