摘要
目的:探讨不良妊娠结局的危险因素及血清中抗核抗体(ANA)和抗心磷脂抗体(ACA)检测的临床意义。方法:选取2017年12月至2018年12月湖北民族大学附属民大医院产科收治的200例不良妊娠结局孕妇作为观察组;另外,选择本院同期行早期孕期检查的200例健康女性作为对照组。对比两组基础资料及实验室检查结果[年龄、孕周、孕次、体重指数(Ibm)、收缩压(SBP)、舒张压(DBP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)、血糖(Glu)、吸烟史、饮酒史及ANA、ACA],同时将有差异的信息纳入Logistic模型行多因素分析,明确不良妊娠结局的影响因素。结果:两组年龄、孕周、孕次、Ibm、SBP、DBP、ALT、AST、BUN、Cr、Glu、饮酒史、吸烟史比较,差异无统计学意义(P>0.05);观察组ANA、ACA阳性及ANA+ACA阳性检出率显著高于对照组(P<0.05)。多因素Logistic回归分析显示,ANA、ACA阳性及ANA+ACA阳性是不良妊娠结局的危险因素(P<0.05)。结论:不良妊娠结局孕妇ANA、ACA阳性及ANA+ACA阳性检出率高,且ANA、ACA阳性及ANA+ACA阳性是不良妊娠疾病的危险因素,临床医师应当给予关注。
Objective:To explore the risk factors of adverse pregnancy outcome and the clinical significance of detection of antinuclear antibody(ANA)and anticardiolipin antibody(ACA)in serum.Methods:200 pregnant women with adverse pregnancy outcomes admitted to the Department of Obstetrics of Minda Hospital of Hubei Minzu University from December 2017 to December 2018 were selected as the observation group;and200 healthy women who received early pregnancy examination in the same period were selected as the control group.The basic data and laboratory results of the two groups were compared(such as age;gestational weeks;gestation times;body mass index,Ibm;systolic blood pressure,SBP;diastolic blood pressure,DBP;alanine aminotransferase,ALT;aspertate aminotransferase,AST;blood urea nitrogen,BUN;creatinine,Cr;blood glucose,Glu;smoking history,drinking history,antinuclear antibody,ANA;anticardiolipin antibody,ACA).The differential factors were included in the Logistic model for multivariate analysis to identify the influencing factors of adverse pregnancy outcome.Results:There were no statistically significant difference in age,gestational weeks,gestation times,Ibm,SBP,DBP,ALT,AST,BUN,Cr,Glu,smoking history,drinking history between the two groups(P>0.05).The positive rates of ANA,ACA,and ANA+ACA in the observation group were significantly higher than those in the control group(P<0.05).Multivariate Logistic regression analysis showed that positive ANA,ACA,and ANA+ACA were risk factors for adverse pregnancy outcome(P<0.05).Conclusion:The positive rates of ANA,ACA,and ANA+ACA in pregnant women with adverse pregnancy outcome are high,and the positive ANA,ACA,and ANA+ACA are the risk factors for adverse pregnancy diseases,which clinicians should pay more attention.
作者
余倩
王露
王文
李丽
Yu Qian;Wang Lu;Wang Wen;Li Li(Department of obstetrics,Minda Hospital of Hubei Minzu University,Hubei Provincial Key Laboratory of Occurrence and Intervention of Rhumatic diseases of Hubei Minzu University,Enshi 445000,China)
出处
《广西医科大学学报》
CAS
2020年第3期454-458,共5页
Journal of Guangxi Medical University
基金
湖北省重点实验室第三批(2017年度)开放基金项目[鄂重点实验室文(2018)01号]。
关键词
不良妊娠
抗核抗体
抗心磷脂抗体
adverse pregnancy
antinuclear antibody
anticardiolipin antibody
