摘要
目的联合静息态功能磁共振成像(resting-state functional MRI,rs-fMRI)中较常用的低频振幅(amplitude of low-frequency fluctuation,ALFF)及局部一致性(regional homogeneity,ReHo)两种分析方法探讨颈总动脉交感神经网剥脱术对单侧痉挛型脑瘫患儿脑功能的影响。材料与方法对21例单侧痉挛型脑瘫患儿手术前1周及手术后14d分别进行常规序列及rs-fMRI检查。利用静息态脑功能数据辅助处理(data processing assistant for resting-state fMRI,DPARSF)软件对图像进行预处理并获取ALFF及ReHo值。采用配对样本t检验比较21例单侧例痉挛型患儿手术前和手术后ALFF及ReHo值差异。结果术后14 d脑瘫患儿患侧大脑半球多个脑区ALFF值和(或)ReHo升高,健侧小脑前叶ALFF值升高(P<0.05);术后14 d脑瘫患儿健侧多个脑区的ALFF值和(或)ReHo降低,患侧额上回ALFF及ReHo值降低(P<0.05)。结论rs-fMRI结果表明,颈总动脉交感神经网剥脱术主要提高单侧痉挛型脑瘫患儿患侧与运动以及认知功能相关脑区区域神经元自发低频振荡活动强度,加强脑区的功能联系。
Objective:To investigate the effect of cervical perivascular sympathectomy on brain function in children with cerebral palsy by using resting-state functional MRI(rs-fMRI).Materials and Methods:Twenty-one children with hemiplegic cerebral palsy underwent routine MRI and rs-fMRI scanning before and after operation.Data processing assistant for rsfMRI(DPARSF)software package was used to process.Paired sample t-test was performed to compare the differences of amplitude of low-frequency fluctuation(ALFF)and regional homogeneity(ReHo)values before and after the operation.Results:Compared with pre-operation,increased ALFF and(or)ReHo was found in the multiple brain regions of the affected side,in the normal side,the ALFF increased in cerebellum anterior lobe(P<0.05).Decreased ALFF and(or)ReHo was found in multiple brain regions of the normal side,in the affected side,ALFF and ReHo decreased in superior frontal gyrus.Conclusions:The results of rs-fMRI show that cervical perivascular symphathectomy improve the spontaneous low-frequency oscillation activity of neurons in related areas,and strengthen the functional connection of relevant brain regions.
作者
艾洁尔古丽·麦合苏木
宋娟
谢超
王云玲
AIJIEERGULI·MAIHESUMU;SONG Juan;XIE Chao;WANG Yunling(Department of Radiology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Radiology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《磁共振成像》
CAS
2020年第4期259-263,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81660202)。
关键词
低频振幅
局部一致性
功能磁共振成像
脑瘫
amplitude of low-frequency fluctuation
regional homogeneity
functional magnetic resonance imaging
cerebral palsy
