摘要
目的采用静息态功能磁共振成像(resting state functional MRI,rs-fMRI)低频振幅(amplitude of low-frequency fluctuation,ALFF)方法探究多系统萎缩(multiple system atrophy,MSA)患者认知相关的自发脑活动改变。材料与方法对29例认知功能正常的MSA患者(MSA-normal cognition,MSA-NC)、33例伴轻度认知功能障碍的MSA患者(MSA-mild cognitive impairment,MSA-MCI)与33名健康对照者(healthy control,HC)进行rs-fMRI扫描。应用ALFF方法比较各组间自发脑活动改变,并对患者组间存在差异脑区的ALFF值与认知评分进行相关性分析。结果与HC相比,MSA-NC在左侧角回及右侧颞中回出现ALFF增强;与HC相比,MSA-MCI在双侧背外侧前额叶、内侧前额叶、前扣带回、中扣带回出现ALFF减低,而在双侧颞下回、角回、左侧枕中回、右侧颞中回、楔前叶及右侧小脑、小脑蚓出现ALFF增强。与MSA-NC相比,MSA-MCI在右侧额叶皮层出现ALFF减低,并与蒙特利尔认知评估量表(montreal cognitive assessment scale,MoCA)评分呈正相关(r=0.531,P<0.05);在右侧小脑出现ALFF增强,并与MoCA评分呈负相关(r=-0.499,P<0.05)。结论MSA特异的轻度认知功能障碍是由小脑与额叶皮层损伤共同介导,其中小脑起到代偿作用。
Objective:To investigate cognitive-related changes of spontaneous activity in multiple system atrophy(MSA)patients using amplitude of low-frequency fluctuation(ALFF)approach.Materials and Methods:Resting state functional magnetic resonance imaging(rsfMRI)data were selected from 29 MSA patients with normal cognitive function(PD-NC),33 MSA patients with mild cognitive impairment(PD-MCI),and 33 healthy controls(HC).ALFF changes were compared between subgroups.Spearman correlation test was taken between patients’ALFF values of changed brain regions and montreal cognitive assessment scale(MoCA)scores.Results:Compared to HC,MSA-NC showed increased ALFF in left angular gyrus and right middle temporal gyrus(MTG).MSA-MCI showed decreased ALFF in bilateral ventral prefrontal cortex(VLPFC),dorsolateral prefrontal cortex(DLPFC),anterior and middle cingulum cortex(ACC,MCC)compared to HC,while it showed increased ALFF in bilateral inferior temporal gyrus(ITG),angular gyrus,left middle occipital gyrus,right middle temporal gyrus(MTG),precuneus,right cerebellum and vermis in the same comparison.Compared to MSA-NC,MSA-MCI showed decreased ALFF in right frontal lobe and increased ALFF in right cerebellum.In addition,MSA patients’ALFF values in right frontal lobe were positively correlated with MoCA scores(r=0.531,P<0.05),while the correlation was negative in the right cerebellum(r=-0.449,P<0.05).Conclusions:Functional damage in frontal lobe and cerebellum are associated with MSA specific mild cognitive impairment,and the cerebellum may play a compensatory role.
作者
李英美
杨华光
范国光
LI Yingmei;YANG Huaguang;FAN Guoguang(Department of Radiology,the First Hospital of China Medical University,Shenyang 110001,China)
出处
《磁共振成像》
CAS
2020年第4期246-252,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
辽宁省特聘教授基金(编号:辽教发[2014]187号)。
关键词
多系统萎缩
轻度认知功能障碍
功能磁共振成像
低频振幅
multiple system atrophy
mild cognitive impairment
functional magnetic resonance imaging
amplitude of low-frequency fluctuation
