摘要
目的研究奥美拉唑联合曲美布汀治疗反流性食管炎的临床效果。方法根据随机数字表法将2017年6月至2018年5月本院接收的82例反流性食管炎患者分为对照组和观察组,每组41例。对照组单一采用奥美拉唑治疗,观察组采用奥美拉唑联合曲美布汀治疗。比较两组患者的治疗效果。结果观察组的各项临床症状消失时间均短于对照组(P<0.05)。观察组的GerdQ各维度评分以及总分均显著低于对照组(P<0.05)。治疗后,两组的C反应蛋白、IL-6水平均降低,且观察组低于对照组(P<0.05)。治疗后,观察组的UESP、LESP及括约肌松弛率均高于对照组及治疗前(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。结论奥美拉唑与曲美布汀联合应用于反流性食管炎患者中安全有效,有助于临床症状和食管动力的改善,还可减轻炎症反应,预后效果良好。
Objective To study the clinical effect of omeprazole combined with trimebutine on reflux esophagitis.Methods According to the random number table method,82 patients with reflux esophagitis received by our hospital from June 2017 to may 2018 were divided into control group and observation group,with 41 cases in each group.The control group was treated with omeprazole alone,and the observation group was treated with omeprazole combined with trimebutine.The therapeutic effects of the two groups were compared.Results The disappearance times of all clinical symptoms in the observation group were shorter than those in the control group(P<0.05).The scores of all dimensions and total score of GerdQ in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of C-reactive protein and IL-6 in both groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the UESP,LESP and sphincter relaxation rate in the observation group were higher than those in the control group and before treatment(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of omeprazole and trimebutine is safe and effective in patients with reflux esophagitis,which can improve the clinical symptoms and esophageal motility,reduce inflammation,with a good prognosis.
作者
宁继
NING Ji(Tianjin Hospital of Ningqiang County,Hanzhong 724400,China)
出处
《临床医学研究与实践》
2020年第8期71-73,共3页
Clinical Research and Practice
