摘要
垂体腺瘤占颅脑肿瘤的15%~20%,其发病率仅次于脑胶质瘤和脑膜瘤。虽然垂体腺瘤是良性肿瘤,但也有部分垂体腺瘤具有恶性倾向的肿瘤生物学特征,易向肿瘤周围组织器官如硬脑膜、海绵窦、蝶窦等浸润性生长,破坏鞍区和颅底正常的解剖结构,临床上称之为侵袭性垂体腺瘤。侵袭性垂体腺瘤采用外科手术完全切除极其困难,而且术后复发率很高,术后常需放化疗等辅助治疗才能控制病情,是当前神经外科领域亟需解决的一大难题。垂体腺瘤侵袭性相关研究是目前神经系统疾病科研领域的热点之一,本文对垂体腺瘤侵袭性相关生物学标志物的研究进行综述。
Pituitary adenomas account for 15%to 20%of craniocerebral tumors,and the incidence of pituitary adenomas is second only to gliomas and meningiomas.Although pituitary adenomas are benign tumors,some pituitary adenomas have malignant biological characteristics.They tend to invade surrounding tissues and organs,such as dura mater,cavernous sinus and sphenoid sinus,and destroy the normal anatomical structure of sellar region and skull base.They are clinically called invasive pituitary adenomas.It is extremely difficult for invasive pituitary adenomas to be completely resected by surgery,and the recurrence rate is very high.The adjuvant treatment such as radiotherapy and chemotherapy is often needed to control the disease after surgery,which is a major problem to be solved urgently in the field of neurosurgery.The research on invasiveness of pituitary adenomas is one of the hotspots in the field of neurological diseases.In this paper,the research on biological markers related to invasiveness of pituitary adenomas is briefly reviewed.
作者
麦麦提依明·托合提
吴永刚
马驰原
MAMATEMIN Tohti;WU Yong-gang;MA Chi-yuan(Department of Neurosurgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)
出处
《临床神经外科杂志》
CAS
2020年第2期228-231,共4页
Journal of Clinical Neurosurgery
基金
新疆维吾尔自治区自然科学基金资助项目(2016D01C121)。
关键词
垂体腺瘤
侵袭性
标志物
pituitary adenomas
invasiveness
biomarker
