摘要
目的:探讨神经生长因子(NGF)在乳腺癌中的表达及临床意义.方法:选取2015年1月~2018年6月我院保存的乳腺癌组织标本70例(乳腺癌组),同时选取正常乳腺组织62例(正常乳腺组),采用免疫组化染色法检测NGF蛋白表达.结果:乳腺癌组NGF蛋白阳性表达率为80.00%,明显高于正常乳腺组(P<0.05);TNM分期Ⅲ~Ⅳ期、中低分化和有淋巴结转移患者NGF蛋白阳性表达率为93.33%、97.92%和97.30%,明显高于Ⅰ~Ⅱ期、高分化和无淋巴结转移患者(P<0.05);NGF蛋白阳性和阴性表达者平均总体生存时间分别为35.27个月(95%CI:32.73~37.81)和36.64个月(95%CI:33.89~39.40),差异比较无统计学意义(P>0.05).结论:乳腺癌组织中NGF呈高表达,与患者临床病理特征有关,与患者预后无明显关系.
Objective:To investigate the expression and clinical significance of nerve growth factor(NGF)in breast cancer.Methods:From January 2015 to June 2018,70 breast cancer specimens(breast cancer group)and 62 normal breast tissues(nonnal breast group)were selected,the expression of NGF protein were detected by immunohistochemical staining.Results:The positive expression rate of NGF protein in breast cancer group was 80.00%,which was significantly higher than that in normal breast group(P<0.05);The positive expression rates of NGF protein in TNM stage Ⅲ-Ⅳ,middle-low differentiation and lymph node metastasis patients were 93.33%,97.92% and 97.30%,which were significantly higher than those in stage Ⅰ-Ⅱ,well-differentiated and non-lymph node metastasis patients(P<0.05);The mean overall survival time of NGF positive and negative expression was 3527 months(95%CI:32.73-37.81)and 36.64 months(95%CI:33.89-39.40P),the difference was not statistically significant(P>0.05).Conclusion:The expression of NGF in breast cancer tissues is high,which is related to the clinicopathological features of the patients,and had no signifies nt relationship with the prognosis of the patients.
作者
李蕾蕾
LI Lei-lei(Luoyang central hospital affiliated to Zhengzhou university,Henan zhengzhou 471009)
出处
《医学检验与临床》
2019年第11期9-12,共4页
Medical Laboratory Science and Clinics
关键词
神经生长因子
乳腺癌
临床病理
预后
Nerve growth factor
Breast cancer
Clinicopathology
Prognosis
