摘要
胎儿生长受限(FGR)是一种严重危害胎儿宫内生长发育的疾病,可导致胎儿宫内缺氧、新生儿窒息、死胎等围生期不良事件,影响胎儿的健康,是导致围生儿死亡的第二位原因。FGR存在肾脏血流异常、肾脏细胞凋亡、肾脏、信号通路异常,胎儿肾脏结构发育和肾脏功能异常。除此之外,FGR还可增加胎儿出生后肾脏疾病和高血压等疾病的发生风险。深入研究FGR与肾脏发育的关系及其导致肾脏疾病的机制,可使宫内干预成为可能,并降低疾病的发生率。
Fetal growth restriction(FGR) is a disease that seriously endangers intrauterine growth and development,and can lead to perinatal adverse events such as stillbirth,fetal hypoxia and neonatal asphyxia,which is the second leading cause of perinatal death.The abnormal renal blood flow kidney cells apotosis and abnormal renal signaling pathway in FGR can lead to abnormal development of fetal kidney structure in the uterus and abnormal fetal kidney function.In addition,FGR can also increase the risk of post-birth kidney disease and hypertension.Deep research on the relationship between FGR and kidney development,and the mechanism leading to kidney disease,can increase the possibility of intrauterine intervention and reduce the incidence of the disease.
作者
孙莲莲
时青云
SUN Lianlian;SHI Qingyun(Department of Obstetrics,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)
出处
《医学综述》
2020年第6期1046-1050,共5页
Medical Recapitulate
基金
国家自然科学基金(81471521)。
关键词
胎儿生长受限
宫内发育迟缓
肾脏发育
作用机制
肾脏损伤
Fetal growth restriction
Intrauterine growth retardation
Kidney development
Action mechanism
Kidney damage
