运动对线粒体稳态调控机制的研究述评——基于运动介导TFEB调节线粒体质量控制的关键机制探讨被引量：8

A Review on the Regulation of Mitochondrial Homeostasis Controlled by Exercise——The Key Mechanism of Exercise-mediated Transcription Factor EB in Regulation of Mitochondrial Quality Control

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摘要线粒体稳态是线粒体形态、结构、数量、体积、质量及功能总是维持相对稳定的动态平衡的一种功能状态。转录因子EB(transcription factor EB,TFEB)介导的线粒体质量控制是维护线粒体稳态调控系统的重要内源性信号调节装置。运动可介导TFEB促进线粒体生物发生,增加线粒体数量和体积,改善线粒体功能;运动可能介导TFEB调节线粒体融合分裂循环的动态平衡,进而重塑线粒体网络结构;运动还可介导TFEB启动线粒体自噬,促进受损、衰老或非功能线粒体的靶向降解,进而维持线粒体数量、质量及功能完整性。提示,运动可介导TFEB构建线粒体生物发生、线粒体融合分裂循环和线粒体自噬等动态协调过程的信号联动机制,进而稳定线粒体质量控制,确保线粒体稳态调控系统的功能完整性。未来以运动介导TFEB调节线粒体质量控制为关键靶点的系列研究,将会进一步丰富与完善线粒体稳态调控系统的分子信号理论。 The mitochondrial morphology,structure,quantity,volume,quality and function are always in a stable state,which is defined as mitochondrial homeostasis.TFEB-mediated mitochondrial quality control is an important endogenous signaling regulatory mechanism in regulating mitochondrial homeostasis.Exercise-mediated TFEB can promote the mitochondrial biogenesis,increase the number and volume of mitochondria,and eventually improve the mitochondrial function.Exercise-mediated TFEB may affect mitochondrial fusion and fission,and eventually remodel the structure of mitochondrial network.In addition,exercisemediated TFEB can also initiate mitophagy,promote the degradation of damaged,aging or nonfunctional mitochondria,and eventually improve the integrity of mitochondrial quantity,quality and function.It is suggested that exercise-mediated TFEB can establish a dynamic signal coupling mechanism among mitochondrial biogenesis,mitochondrial fusion and fission cycle,and mitophagy,which eventually improve mitochondrial quality control and ensure the functional integrity of mitochondrial homeostasis system.The future studies which focus on exercise-mediated TFEB in regulating mitochondrial quality control will further enrich and prefect the molecular signal theory of mitochondrial homeostasis regulation.

作者钱帅伟孙易漆正堂丁树哲 QIAN Shuaiwei;SUN Yi;QI Zhengtang;DING Shuzhe(Wuhan Sports University,Hubei Key Laboratory of Exercise Training and Monitoring,Wuhan 430079,China;East China Normal University,Key Laboratory of Adolescent Health Assessment and Exercise Intervention,Ministry of Education,Shanghai 200241,China;Yantai University,College of Physical Education,Yantai 264005,China)

机构地区武汉体育学院华东师范大学烟台大学体育学院

出处《体育科学》 CSSCI 北大核心 2020年第2期70-82,共13页 China Sport Science

基金国家自然科学基金项目(31671241) 山东省自然科学基金青年基金项目(ZR2017QC002) 武汉体育学院“东湖学子”特聘岗位资助项目(2019)。

关键词转录因子EB 运动线粒体稳态线粒体质量控制 transcription factor EB exercise mitochondrial homeostasis mitochondrial quality control

分类号 G804.6 [文化科学—运动人体科学]