摘要
糖尿病是一种以高血糖为特征的代谢性疾病,肌少症是其常见的慢性并发症之一。糖尿病性肌少症可能与泛素-蛋白酶体系统、胰岛素抵抗、氧化应激、线粒体损伤、胰岛素信号通路、晚期糖基化终末产物有关。本文根据国内外文献,对糖尿病性肌少症的发病机制和治疗靶点进行综述。
Diabetes is a kind of metabolic diseases characterized by hyperglycemia.Sarcopenia is one of the common diabetic complications.Development of diabetic sarcopenia is related to ubiquitin-proteasome system,insulin resistance,oxidative stress,mitochondria damage,insulin signaling pathway and advanced glycationend products.This review summarized the pathological mechanism and treatment targets for diabetic sarcopenia based on national and international literatures.
作者
丁凡
李文雄
张佳莉
张岩
DING Fan;LI Wenxiong;ZHANG Jiali;ZHANG Yan(Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education,Shanghai 200032,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2019年第12期1428-1433,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金资助项目(81774329)
上海市市级医疗卫生优秀学科带头人培养计划资助(2018BR03)
上海市优秀学术带头人计划资助(19XD1423800)
科技部重大新药创制资助(2019ZX09201004-003-032)
教育部创新团队(IRT1270)
上海市自然科学基金(17ZR1430800)
