摘要
目的:观察小儿止泻汤的药物疗效及对小儿腹泻患者的临床效果。方法:纳入120例小儿腹泻患者随机分为对照组和观察组各60例。对照组行常规对症治疗,包括补充电解质、纠酸联合蒙脱石散、枯草杆菌二联活菌颗粒治疗,观察组在对照组基础上加服小儿止泻汤。比较2组治疗前后血清炎症因子血清白细胞介素-1 (IL-1)、白细胞介素-6 (IL-6)及肿瘤坏死因子-α(TNF-α)水平、腹泻停止、临床症状改善时间及总病程。结果:观察组总有效率91.67%,高于对照组的81.67%(P<0.05)。治疗第1天,IL-1、TNF-α、IL-6均有所降低,但差异无统计学意义(P>0.05);治疗第3天,观察组IL-1、TNF-α、IL-6水平均低于对照组(P<0.05)。观察组患儿经治疗后腹泻停止时间、临床症状改善时间、总病程较对照组明显缩短,差异有统计学意义(P<0.05)。结论:小儿止泻汤能显著减轻腹泻患儿症状,减少患儿体内炎症因子释放,减轻炎症反应,缩短病程对腹泻患儿有较好药物疗效。
Objective: To observe curative effect of Xiao’er Zhixie tang and its clinical effect on diarrhea in children.Methods:A total of 120 cases of children with diarrhea were randomly divided into the control group and the observation group,60 cases in each group. The control group was treated with routine symptomatic treatments including supplement of electrolyte, correction of acidosis combined with montmorillonite powder as well as live combined Bacillus subtilis and Enterococcus faecium granules. The observation group was additionally treated with Xiao’er Zhixie tang based on the treatment of the control group. The levels of inflammatory factors including interleukin-1(IL-1),IL-6 and tumor necrosis factor-α(TNF-α) in serum before and after treatment,the stopping time of diarrhea,the time of improvement of clinical symptoms and the total course of disease in the two groups were compared. Results:The total effective rate was 91.67% in the observation group,higher than that of 81.67% in the control group(P<0.05). On the first day of treatment,there was no significant difference being found in the comparison of the counts of leukocytes and erythrocytes in feces in the two groups(P>0.05);the levels of IL-1,TNF-α and IL-6 were all decreased,but there being no significance in the difference(P>0.05). On the third day of treatment,the levels of IL-1,TNF-α and IL-6 in the observation group were all lower than those in the control group(P<0.05). After treatment, the stopping time of diarrhea and the time of improvement of clinical symptoms in the observation group were significantly earlier,and the total course of disease was significantly shortened than those in the control group,the difference being significant(P<0.05). Conclusion:Xiao’er Zhixie tang has good curative effect in treating children with diarrhea, which can significantly reduce the symptoms of diarrhea, the release of inflammatory factors and the inflammatory responses,and shorten the course of disease.
出处
《新中医》
CAS
2020年第4期108-110,共3页
New Chinese Medicine
关键词
腹泻
中西医结合疗法
小儿止泻汤
蒙脱石散
枯草杆菌二联活菌颗粒
Diarrhea
Traditional Chinese and western medicine therapy
Xiao’er Zhixie tang
Montmorillonite powder
Live combined Bacillus subtilis and Enterococcus faecium granules
