摘要
目的了解银川市2型糖尿病(type 2 diabetes mellitus,T2DM)住院患者健康相关生命质量(health-related quality of life,HRQOL)现状,分析影响T2DM住院患者HRQOL的因素;探讨分位数回归分析HRQOL影响因素的应用价值。方法使用横断面调查的方法获得480例T2DM住院患者的资料,采用中文版糖尿病相关生命质量(Chinese normal audit of diabetes-dependent quality of Life,CN-ADDQoL)量表评估患者的HRQOL状况,比较应用传统线性回归和分位数回归模型分析T2DM住院患者HRQOL影响因素的结果。结果 T2DM住院患者平均加权影响得分(average weight impact,AWI)为-2.7(-3.6,-1.9),得分最低的条目是"工作生涯"(AWI,-4(-6,-2)),"吃东西随意性"(AWI,-4(-6,-2))和"喝东西随意性"(AWI,-4(-6,-2))。线性回归结果显示,年龄18~59岁(β=0.465,P=0.001)、有肾脏(β=-0.375,P=0.012)和循环系统并发症(β=-0.287,0.036)是T2DM住院患者HRQOL的危险因素。分位数回归进一步发现,生命质量越好,年龄对其影响越弱(β_1=0.931,P_1=0.001;β_2=0.699,P_2=0.001;β_3=0.370,P_3=0.012;β_4=0.313,P_4=0.035);农村居民(β_5=-0.421,P_5<0.001)、接受胰岛素治疗(β_3=-0.325,P_3=0.024)、眼部(β_1=-0.546,P_1=0.008;β_5=-0.352,P_5=0.008)、肾脏(β_5=-0.358,P_5=0.025)及循环系统并发症(β_1=-0.803,P_1<0.001;β_5=-0.302,P_5=0.011)在个别百分位点上对HRQOL有影响。结论年龄、城乡居住地、是否接受胰岛素治疗、合并并发症是T2DM住院患者HRQOL的影响因素,分位数回归模型可以分析在不同百分位点上影响患者生命质量的因素,为不同HRQOL患者生命质量的提高提供有针对性的合理建议。
Objective This study aimed to understand the status of health-related quality of life(HRQOL)among the hospitalized patients with type 2 diabetes(T2 DM)in Yinchuan,so as to analyze the factors associated with HRQOL of hospitalized T2 DM patients.The applied value of quantile regression in analysis of HRQOL was explored.Methods A cross-sectional study was conducted to obtain data of 480 hospitalized T2 DM patients.The Chinese Normal Audit of Diabetes-Dependent Quality of Life(CN-ADDQoL)scale was used to assess the HRQOL status of patients.Traditional linear regression and quantile regression were used to analyze the influencing factors of HRQOL in hospitalized T2 DM patients.Results The average weight impact(AWI)of hospitalized T2 DM patients was-2.7(-3.6,-1.9),and the items with lowest score were in the dimension of"work life"(AWI,-4(-6,-2)),"eat"AWI,-4(-6,-2)and"Anything of Drinking"(AWI,-4(-6,-2)).Linear regression results showed that 18-59 years old or the renal and circulatory complications were risk factors for HRQOL in T2 DM hospitalized patients.Quantile regression further found that the better the quality of life,the weaker the effect on age(β1=0.931,P1=0.001;β2=0.699,P2=0.001;β3=0.370,P3=0.012;β4=0.313,P4=0.035),the rural residents(β5=-0.421,P5<0.001),insulin treatment(β3=-0.325;P3=0.024),the ocular(β1=-0.546,P1=0.008;β5=-0.352,P5=0.008),renal(β5=-0.358,P5=0.025)and circulatory complications(β1=-0.803,P1<0.001;β5=-0.302,P5=0.011)had effect on HRQOL at different quantiles.Conclusions Age,urban and rural residence,whether receive insulin therapy and complications are the influencing factors of HRQOL in hospitalized T2 DM patients.The quantile regression model can show different factors affecting the quality of life of patients at different quintiles.The results from quantile regression can provide the targeted and reasonable recommendations for improvement of HRQOL of T2 DM patients.
作者
张静
孙仙
张文玲
李金霞
田小丽
ZHANG Jing;SUN Xian;ZHANG Wen-ling;LI Jin-xia;TIAN Xiao-li(Department of Epidemiology and Health Statistics,School of Public Health and Management,Ningxia Medical University,Yinchuan 750004,China;Department of Medical,Shizuishan First People's Hospital,Shizuishan 753600,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2020年第2期183-188,共6页
Chinese Journal of Disease Control & Prevention
基金
宁夏医科大学校级科研项目(XY201732)
大学生创新训练项目(NXCX2017115)。
