摘要
目的探讨肺癌化疗患者癌因性疲乏(CRF)影响因素及其与生存质量的关系。方法选取121例晚期肺癌化疗患者为研究对象,依据国际疾病分类标准第10版相关标准诊断CRF,使用Piper疲乏量表中文修订版(RPFS)、肺癌治疗功能评价系统(FACT-L)分别评估CRF程度及生活质量。采用多因素logistic回归分析CRF发生的影响因素,Spearman秩相关分析CRF与生存质量的相关性。结果发生CRF 89例(73.6%),以中度疲乏(59例,66.3%)为主。家庭月收入(OR=0.399)、临床分期(OR=4.809)、化疗次数(OR=5.287)及血白细胞计数(OR=0.763)、血红蛋白水平(OR=0.977)是肺癌化疗患者发生CRF的影响因素(均P<0.05)。肺癌化疗患者RFPS总体及4个维度(行为疲乏、情感疲乏、躯体疲乏、认知疲乏)评分与FACT-L 5个维度(生理状况、社会状况、情感状况、功能状态、肺癌相关症状)评分均呈负相关(均P<0.05)。结论家庭月收入、肿瘤临床分期、化疗次数及血白细胞计数、血红蛋白水平是肺癌化疗患者发生CRF的影响因素。患者CRF程度越重,其生存质量越低。
Objective To investigate the influencing factors of cancer-related fatigue(CRF)and its correlation with the quality of life in lung cancer patients undergoing chemotherapy.Methods A total of 121 patients with advanced lung cancer undergoing chemotherapy were recruited.CRF was diagnosed according to relevant criteria in international classification of diseases(10th edition),and CRF degree and quality of life were evaluated by the Piper fatigue scale(RPFS)and the lung cancer treatment function evaluation system(FACT-L).Logistic regression and Spearman rank correlation were used to analyze the influencing factors of CRF and its correlation with quality of life.Results CRF occurred in 89 cases(73.6%),mainly was moderate fatigue(59 cases,66.3%).Family monthly income level(OR=0.399),clinical stage(OR=4.809),number of chemotherapy cycle(OR=5.287),white blood cell count(OR=0.763),hemoglobin level(OR=0.977)were the influencing factors for the occurrence of CRF(all P<0.05).The RFPS scores of the total and 4 dimensions(behavioral fatigue,emotional fatigue,physical fatigue and cognitive fatigue)of the cancer chemotherapy patients were negatively correlated with the scores of the 5 dimensions of FACT-L(physiological status,social status,emotional status,functional status,and lung-related symptoms)(all P<0.05).Conclusion Family monthly income level,clinical stage of tumor,number of chemotherapy cycle,white blood cell count and hemoglobin level are the influencing factors of CRF in lung cancer patients undergoing chemotherapy;and the degree of CRF is negatively correlated with the quality of life.
作者
李艳
徐象威
朱佩祯
陈银巧
李安康
LI Yan;XU Xiangwei;ZHU Peizhen(Department of Oncology,Yongkang First People’s Hospital,Yongkang 321300,China)
出处
《浙江医学》
CAS
2020年第4期361-364,共4页
Zhejiang Medical Journal
基金
金华市公益类科学技术研究计划项目(2018-4-154)。
关键词
肺癌
化疗
癌因性疲乏
生存质量
Lung neoplasm
Chemotherapy
Cancer related fatigue
Quality of life
