摘要
目的探讨磁共振成像联合血清学检测在新生儿缺血缺氧性脑病诊断的应用效果。方法选取该院2017年12月至2018年12月60例临床确诊为新生儿缺血缺氧性脑病的患儿,采用磁共振成像(MRI)进行检测,并联合使用血清学检测,检测缺氧诱导因子-1(HIF-1),分析对新生儿缺血缺氧性脑病的诊断结果。结果根据磁共振成像的影像学情况,60例患儿中有26例脑出血及蛛网膜下腔出血,16例局灶性脑水肿伴基底节损伤,13例广泛性脑水肿伴基底节损伤,11例单纯性脑水肿。各组病例中,HIF-1蛋白检测从低到高依次为单纯性脑水肿组、局灶性脑水肿伴基底节损伤组、广泛性脑水肿伴基底节损伤组、脑出血及蛛网膜下腔出血组,组间数据差异有统计学意义(P<0.05)。结论磁共振成像联合血清学检测对新生儿缺血缺氧性脑病的诊断有重要的价值,有助于为临床诊断和治疗提供参考。
【Objective】To explore the application of magnetic resonance imaging(MRI)combined with serological detection in the diagnosis of neonatal hypoxic ischemic encephalopathy.【Methods】From December 2017 to December 2018,60 children with clinically diagnosed neonatal hypoxic ischemic encephalopathy were enrolled.MRI combined with serological detection was used.Hypoxia-inducible factor-1(HIF-1)was used to analyze the diagnosis of neonatal hypoxic ischemic encephalopathy.【Results】According to the imaging apperance of MRI,there were 26 cases of cerebral hemorrhage and subarachnoid hemorrhage in 60 cases,16 cases of focal cerebral edema with basal ganglia injury,13 cases of extensive cerebral edema with basal ganglia injury,11 cases of simple brain edema.In each group,HIF-1 protein detection from low to high was simple cerebral edema group,focal cerebral edema with basal ganglia injury group,extensive cerebral edema with basal ganglia injury group,cerebral hemorrhage and subarachnoid hemorrhage group;there were statistically significant differences among groups(P<0.05).【Conclusion】Magnetic resonance imaging combined with serological detection is of great value in the diagnosis of neonatal hypoxic ischemic encephalopathy,and it is helpful to provide reference for clinical diagnosis and treatment.
作者
阎光辉
张杰
卜庆丰
YAN Guanghui;ZHANG Jie;BU Qingfeng(Yangchun City People's Hospital of Guangdong Province CT-MRI department Guangdong Yangjiang,529600)
出处
《中国医学工程》
2019年第11期57-60,共4页
China Medical Engineering
关键词
磁共振成像
血清学检测
新生儿
缺血缺氧性脑病
magnetic resonance imaging
serological testing
neonatal
hypoxic ischemic encephalopathy
