摘要
目的分析肺结核患者滤泡辅助T细胞表达及相关因子谱变化。方法70例初治肺结核患者为本院2017年11月-2018年11月收治的患者,检测患者滤泡辅助性T细胞亚群及其相关因子IL-17、IL-21表达水平,根据肺结核治疗效果分为进展期20例(进展组)、好转期50例(好转组),同时以健康体检的30例患者作为对照组,对比不同病情肺结核患者血清中Tfh、IL-17、IL-21表达水平,以肺结核初治无效为终点事件采用Logistic回归分析探讨影响肺结核初治无效的独立危险因素。结果进展组患者Tfh、IL-17、IL-21水平均明显高于好转组、对照组患者(P<0.05);血清Tfh、IL-17、IL-21与患者胸腔积液呈正相关(P<0.05),与初治效果、肺功能呈负相关(P<0.05);Tfh(P=0.03)、IL-17(P=0.02)、IL-21(P=0.03)是肺结核初始治疗效果无效的独立危险因素。结论肺结核患者Tfh、IL-17、IL-21是肺结核患者预后不良的独立危险因素。
Objective To analyze the expression of follicular helper T cells and the changes of related factor spectrum in patients with pulmonary tuberculosis.Methods Seventy patients with pulmonary tuberculosis were treated in our hospital from November 2017 to November 2018.The levels of follicular helper T lymphocyte subsets and related factors IL-17 and IL-21 were detected.According to the therapeutic effect of pulmonary tuberculosis,they were divided into progressive group(20 cases),improved group(50 cases),and control group(30 cases).The levels of Tfh,IL-17 and IL-21 in the serum of nuclear patients were analyzed by logistic regression analysis to explore the independent risk factors affecting the ineffectiveness of initial treatment of pulmonary tuberculosis.Results The levels of Tfh,IL-17 and IL-21 in the progressive group were significantly higher than those in the improved group and the healthy group(P<0.05).Serum Tfh,IL-17 and IL-21 were positively correlated with pleural effusion and negatively correlated with primary treatment and pulmonary function(P<0.05).Tfh(P=0.03),IL-17(P=0.02)and IL-21(P=0.03)were independent risk factors for invalid initial treatment of tuberculosis.Conclusion Tfh,IL-17 and IL-21 are independent risk factors for poor prognosis of tuberculosis patients.
作者
陈娇君
彭官清
陈锦文
凌乔
CHEN Jiao-jun;PENG Guan-qing;CHEN Jin-wen;LING Qiao(Department of Infectious Diseases,First Peopled Hospital of Wenling,Wenling,Zhejiang 317500,China)
出处
《中国卫生检验杂志》
CAS
2020年第3期343-345,共3页
Chinese Journal of Health Laboratory Technology
关键词
肺结核
滤泡辅助T细胞
细胞因子
预后
Tuberculosis
Follicular helper T cells
Cytokines
Prognosis
