摘要
目的借助乳糖微粉改性技术,降低金银花浸膏粉的吸湿性,解决生产过程中金银花浸膏粉易吸潮、不易存放的问题。方法以吸湿率为评价指标,优选乳糖种类、药辅比、研磨时间等工艺参数,通过中试放大验证改性技术对金银花膏粉吸湿性的改善作用。结果乳糖微粉改性最佳工艺条件为金银花浸膏粉与乳糖超微粉碎(粉碎2 min)等比例研磨3 min,改性物的粒径d 0.1,d 0.5,d 0.9分别为3.412、20.146、76.145μ6,乳糖颗粒包覆在金银花浸膏粉表面。结论乳糖适度微粉化能明显降低金银花浸膏粉的吸湿初速度和吸湿加速度的绝对值,能显著降低金银花浸膏粉的吸湿性,有效解决生产过程中金银花浸膏粉吸湿性严重的实际问题。
Objective With the help of lactose micropowder modification technology to reduce the hygroscopicity of honeysuckle extract powder.It is solved the problem that honeysuckle extract powder is easy to absorb moisture and is difficult to store in the production process.Methods The moisture absorption rate was taken as the evaluation index.And the technological parameters such as lactose type,drug proportion and grinding time were optimized.Modification technology to improve the hygroscopicity of flos lonicerae powder was verified by pilot scale validation.Results Optimal technological conditions of lactose micropowder grinding modification to decrease hygroscopicity of honeysuckle extract powder were as follows:Honeysuckle extract powder-lactose micropowder(crushed 2 min)of 1∶1,grinding time of 3 min.Particle sizes d0.1,d0.5 and d0.9 of modifier were 3.412,20.146,76.145μm respectively.Surface of honeysuckle extract powder was coated by lactose micropowder particles.Conclusion Available micronizing lactose can significantly decrease absolute values of initial velocity and acceleration of moisture absorption of honeysuckle extract powder for reducing its hygroscopicity.It is effectively solved to the problem of serious hygroscopicity of honeysuckle extract powder in the production process.
作者
韦迎春
闫明
贾银芝
杨绪芳
吴云
肖伟
Wei Yingchun;Yan Ming;Jia Yinzhi;Yang Xufang;Wu Yun;Xiao Wei(Jiangsu Kanion pharmaceutical Co.,Ltd.,Lianyungang 222047,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Lianyungang 222047,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2019年第9期1956-1961,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家中医药管理局国家中药标准化研究专项（ZYBZH-C-JS-31）：热毒宁注射液标准化建设，负责人：萧伟
关键词
金银花浸膏粉
乳糖微粉
研磨改性
吸湿性
粒径分布
Honey suckle extract power
Lactosemicro powder
Grinding modification
Hygroscopicity
Particle size distribution
