摘要
目的探讨三联疗法治疗幽门螺杆菌(Helicobecter pylori, Hp)所致再发性腹痛患儿的临床疗效。方法将2018年2月至2019年2月铅山县人民医院收治的Hp所致再发性腹痛患儿60例依据随机数字表法分为对照组和观察组,每组30例。对照组采用硫糖铝三联疗法治疗,观察组采用复方猴头颗粒三联疗法治疗。比较两组患儿Hp清除率、疼痛改善情况、炎症介质白细胞介素-6(IL-6)水平及不良反应发生情况。结果观察组Hp清除率高于对照组,治疗4周后,视觉模拟评分法(VAS)评分及IL-6水平均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率略低于对照组,但差异无统计学意义(P>0.05)。结论使用复方猴头颗粒三联疗法治疗小儿再发性腹痛临床疗效显著,可有效清除Hp,减轻炎症反应,缓解疼痛,且用药安全性较高。
Objective To explore the clinical effects of triple therapy on children with recurrent abdominal pain caused by Helicobacter pylori. Methods A total of 60 children with recurrent abdominal pain caused by HP admitted to the People’s Hospital of Qianshan County from February 2018 to February 2019 were divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with sucralfate triple therapy, and the observation group was treated with Compound Houtou Granule triple therapy. The clearance rate of HP, the improvement of pain, the level of Interleukin-6(IL-6) and the occurrence of adverse reactions were compared between the 2 groups. Results The Hp clearance rate of observation group was higher than that of control group, and after treatment for 4 weeks, the Visual Analog Scoring(VAS) score and IL-6 in observation group were lower than those in control group(P<0.05). The total incidence of adverse reactions in observation group was slightly lower than that in control group(P>0.05). Conclusion The clinical effects of Compound Houtou Granule triple therapy in the treatment of children’s recurrent abdominal pain has significant efficacy. It can effectively remove HP, reduce inflammatory reaction, relieve pain, and has high safety of drug use.
作者
占剑青
张东旭
叶志娟
ZHAN Jian-Qing;ZHANG Dong-Xu;YE Zhi-Juan(Qianshan County People's Hospital,Shangrao 334500,China)
出处
《中国药物经济学》
2019年第12期44-46,共3页
China Journal of Pharmaceutical Economics
基金
上饶市科技计划(20191CKJ07)
关键词
再发性腹痛
幽门螺杆菌
三联疗法
Recurrent abdominal pain
Helicobacter pylori
Triple therapy
