摘要
肝细胞癌(HCC)是世界上最致命的恶性肿瘤之一,缺氧与HCC发生发展密切相关。缺氧、缺氧标志物以及缺氧诱导肿瘤新生血管在HCC发生发展机制的研究对临床诊断与治疗有重大意义。笔者就缺氧诱导因子、基质金属蛋白酶、高迁移率族蛋白1、自噬基因Beclin-1、神经红蛋白、细胞红蛋白和microRNAs在HCC中作用机制做一综述。
Hepatocellular carcinoma(HCC)is one of the deadliest cancers in the world.Hypoxia is closely related to the occurrence and development of HCC.The researches on hypoxia,hypoxia markers and hypoxia-induced tumor neovascularization in HCC have great significance for clinical diagnosis and treatment.Here,the authors address the action mechanisms of hypoxia inducible factors,matrix metalloproteinases,high mobility group protein 1,autophagy gene Beclin-1,neuroglobin,cytoglobin and microRNAs(miRNAs)in HCC.
作者
孟永斌
程彬彬
杜娟
陈红云
凌昌全
MENG Yongbin;CHENG Binbin;DU Juan;CHEN Hongyun;LING Changquan(School of Traditional Chinese Medicine,Naval Medical University,Shanghai 200433,China)
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2020年第1期97-103,共7页
China Journal of General Surgery
基金
国家自然科学基金资助项目(81774077)
关键词
癌
肝细胞
低氧
芳香烃受体核转位子
综述文献
Carcinoma, Hepatocellular
Hypoxia
Aryl Hydrocarbon Receptor Nuclear Translocator
Review
