摘要
探索影响水合氯醛溶液稳定性的因素,并预测其有效期。采用加速稳定性实验的方法,研究温度、光照、存放时间等因素对水合氯醛溶液稳定性的影响,确定降解反应的级数,计算室温的降解速度常数(K25℃)和有效期。结果ρ(水合氯醛)=0.1 g/mL水溶液不稳定,久置逐渐分解,遇光分解加速降解反应为一级,室温条件下的有效期为6 d。建议临床使用最好现用现配,配好的药液应阴凉避光保存。
In order to explore the factors that affect the stability of chloral hydrate solution and predict its validty,an accelerated testing method was used.The approach aims to study the effects of temperature,light,storage time and other factors on the stability of chloral hydrate solution,determine the grade of degradation reaction,calculate the degradation rate constant(K25℃)and the validity period.The results indicated that the 0.1 g/mL chloral hydrate aqueous solution was unstable in case of light,temperature,and gradually decomposed with time.The degradation reaction is one grade,and the validty is 6 days at room temperature.It was recommended that the well-prepared solution was stored in a cool and dark place.
作者
冯家星
李惠民
邢丽娜
冯锁民
方宇
FENG Jiaxing;LI Huimin;XING Lina;FENG Suomin;FANG Yu(College of Pharmacy,Medical Department of Xi’an Jiaotong University,Xi’an 710061,China;College of Pharmacy,Xi’an Medical University,Xi’an 710021,China;Shangluo Vocational and Technical College,Shangzhou 726000,China)
出处
《化工科技》
CAS
2020年第1期37-40,共4页
Science & Technology in Chemical Industry
基金
2017年陕西省缺血性心血管疾病重点实验室开发基金项目(2017ZDKF03)
西安医学院省级重点学科-药学项目(1007)
西安医学院药学省级重点学科建设项目(2016YXXK12)
