摘要
目的探讨睾丸蛋白聚糖1(SPOCK1)在宫颈癌中的表达及意义。方法采用免疫组化法检测84例宫颈癌及正常宫颈组织中SPOCK1的表达,并分析SPOCK1与宫颈癌患者临床特征的关系。结果SPOCK1在宫颈癌组织中的阳性表达率为64.29%(54/84),明显高于正常宫颈组织中的4.76%(4/84),差异有统计学意义(P﹤0.01)。低分化、ⅠB~ⅡA期、有淋巴结转移宫颈癌患者的宫颈癌组织中SPOCK1阳性表达率分别明显高于高中分化、ⅠA期、无淋巴结转移患者,差异均有统计学意义(P﹤0.01)。结论SPOCK1在宫颈癌组织中高表达,可作为判断宫颈癌发生发展及淋巴结转移的参考指标。
Objective To explore expression and significance of SPARC/osteonectin,cwcv and kazallike domains proteoglycan 1(SPOCK1)in cervical carcinoma.Method The expression of SPOCK1 in 84 cases of cervical carcinoma and normal tissues were detected by immunohistochemical assay.The relationship between SPOCK1 and clinical pathological parameters was analyzed.Result The positive expression rate of SPOCK1 in cervical carcinoma was 64.29%(54/84),which was higher than that in normal tissues at 4.76%(4/84),showing note worthy difference(P<0.01).The positive expression rate of SPOCK1 in cervical cancer with poor differentiation,stage IB-IIA,and positive lymph node metastasis were significantly higher than that with high and moderate differentiation,stage IA,and negative lymph node metastasis,the differences were of statistical significance(P<0.01).Conclusion The expression of SPOCK1 in cervical carcinoma is high,which might be a reference to determine the occurrence,development and lymph node metastasis of cervical cancer.
作者
魏敏
唐秦
赵林
汪强
WEI Min;TANG Qin;ZHAO Lin;WANG Qiang(Department of Gynecology and Obstetrics,Sichuan Mianyang 404 Hospital,Mianyang 621000,Sichuan,China)
出处
《癌症进展》
2020年第3期268-270,共3页
Oncology Progress
