摘要
目的比较结核菌素试验(TST)和结核感染T细胞斑点试验(T-SPOT.TB)用于肺外结核病(EPTB)辅助诊断的临床价值。方法回顾性分析南通市如东县中医院2017年1月至2019年5月收治的行TST和T-SPOT.TB检测的EPTB患者(64例,EPTB组)和非结核性疾病患者(106例,对照组)的临床资料,比较两种检测技术诊断的灵敏度、特异度、阳性预测值及阴性预测值,并行ROC曲线分析两种方法的诊断效能。结果T-SPOT.TB辅助诊断EPTB的灵敏度、特异度、阳性预测值及阴性预测值均明显优于TST(P<0.05);ROC曲线分析显示,TST和T-SPOT.TB辅助诊断EPTB曲线下面积分别为0.633(95%CI:0.501~0.749)、0.892(95%CI:0.812~0.974)。结论T-SPOT.TB用于EPTB辅助诊断的灵敏度与特异度高,诊断效能佳,临床应用价值优于TST。
Objective To compare the clinical value of tuberculin skin test(TST)and tuberculosis infection T cell spot test(T-SPOT.TB)in the auxiliary diagnosis of extrapulmonary tuberculosis(EPTB).Methods The clinical data of 64 cases of EPTB(EPTB group)and 106 cases of non tuberculosis disease(control group)admitted to Rudong Country Chinese Medicine Hospital from January 2017 to May 2019 undergoing TST and T-SPOT.TB tests were analyzed retrospectively.The sensitivity,specificity,positive predictive value and negative predictive value of the two methods were compared,and the diagnostic efficiency of the two methods was analyzed by ROC curve.Results The sensitivity,specificity,positive predictive value and negative predictive value of T-SPOT.TB were significantly better than those of TST(P<0.05);ROC curve analysis showed that the area under the curve(AUC)of TST and T-SPOT.TB were 0.633(95%CI:0.501-0.749)and 0.892(95%CI:0.812-0.974)respectively.Conclusion T-SPOT.TB has high sensitivity and specificity for EPTB auxiliary diagnosis,and with high diagnostic efficiency,the clinical application value is better than TST.
作者
施爱军
田华
SHI Aijun;TIAN Hua(Department of Clinical Laboratory,Rudong Country Chinese Medicine Hospital,Nantong,Jiangsu 226001,China;Department of Clinical Laboratory,Nantong Sixth People′s Hospital,Nantong,Jiangsu 226400,China)
出处
《检验医学与临床》
CAS
2020年第5期610-612,共3页
Laboratory Medicine and Clinic
关键词
结核菌素试验
结核感染T细胞斑点试验
肺外结核病
诊断
tuberculin skin test
tuberculosis infection T cell spot test
extrapulmonary tuberculosis
diagnosis
