摘要
目的分析维持性血液透析(MHD)患者脂质代谢紊乱和心脑血管疾病之间的关系。方法选取本院血液净化中心2016年1月至2018年12月行MHD的慢性肾功能衰竭患者52例,设为研究组;同时选取同期在本院进行健康体检的52例健康人群,设为对照组。测定两组血液中的总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、载脂蛋白(APOB)以及低密度脂蛋白(LDL)水平,评估两组的心脑血管事件发生情况,分析MHD患者脂质代谢紊乱与心脑血管疾病之间的关系。结果研究组患者的TC、TG、APOB以及LDL水平均明显高于对照组,HDL水平显著低于对照组,组间比较差异有统计学意义(P<0.05)。研究组非心脑血管事件患者的TC、TG、APOB以及LDL水平均显著低于心脑血管事件患者的血脂指标,组间相比较差异有统计学意义(P<0.05)。结论长期的血液透析会导致慢性肾功能衰竭患者体内的蛋白质流失,从而出现脂质代谢紊乱,导致心脑血管的发生率明显增加。
Objective To analyze the relationship between lipid metabolism disorder and cardiovascular and cerebrovascular diseases in patients with maintenance hemodialysis(MHD).Methods A total of 52 patients with chronic renal failure who underwent MHD in our hospital's blood purification center from January 2016 to December 2018 were enrolled in the study group.52 healthy subjects who underwent healthy physical examination in our hospital were selected as the control group.Determination of total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),carrier protein(APOB),and low-density lipoprotein(LDL)levels in the blood of both groups,and to evaluate the occurrence of cardiovascular and cerebrovascular events in both groups.To analyze the relationship between lipid metabolism disorders and cardiovascular and cerebrovascular diseases in MHD patients.Results The levels of TC,TG,APOB and LDL in the study group were significantly higher than those in the control group.The HDL level was significantly lower than that in the control group.There was significant difference between the groups(P<0.05).TC,TG,APOB and LDL levels of patients with non-cardiovascular and cerebrovascular events in the study group were significantly lower than those of patients with cardiovascular and cerebrovascular events,and the differences between the groups were statistically significant(P<0.05).Conclusion Long-term hemodialysis can lead to the loss of protein in patients with chronic renal failure,resulting in disorder of lipid metabolism,resulting in a significant increase in the incidence of cardiovascular and cerebrovascular.
作者
王栗莉
Wang Lili(Department of NephrologyⅠ,Shenyang Fourth People Hospital,Shenyang,Liaoning,110031,China)
出处
《当代医学》
2020年第7期64-66,共3页
Contemporary Medicine
关键词
维持性血液透析
脂质代谢紊乱
心脑血管疾病
相关性
Maintenance hemodialysis
Lipid metabolism disorder
Cardiovascular and cerebrovascular diseases
Correlation
